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CRAGE-CRISPR combo helps further demystify biosynthetic gene clusters.  The Science Microbial … active secondary metabolites and helping them identify and describe the functions of the biosynthetic gene … highly regulated in bacteria, making it difficult to identify which pathway corresponds to which metabolite. Finding a …

… dwell in herbivore guts and help them digest their last leafy meal. In their evolutionary history, these fungi branched … proposal. The next step for the team was to try to identify what natural products the fungi were making. So, Trent … Graduate Research Fellowship Program under Grant No. 1650114, a UCSB Graduate Division Dissertation Fellowship, …

Jarrod Chapman, developed a method to correctly identify polyploid subgenomes without needing to know the genomes … it’s hard to analyze. The ancestors are a bit hard to identify and there’s a small possibility that something could be … on this kind of analysis in more species, as well as modifying this method to study other types of problems …

… more than once, and these events took place a million years apart: the individual with a maternal  B. distachyon parent (D plastotype) some 1.4 million years ago (Mya), while the S plastotype was a more recent … anticipated with only minor gene loss even after a million years.” Reference genomes for  B. distachyon ,  B. stacei …

… a dark room with a flashlight, only able to clearly identify what falls within that single beam. When it comes to … but we knew the families,” Kyrpides said. Yet, “almost 20 years of metagenomic data and metagenomic analysis, and … of new protein families had started to plateau in recent years, perhaps suggesting that scientists had “captured” …

Unique Capability DAP-seq allows researchers to identify all the sites where transcription factors bind quickly … ENCODE project known as FUNCODE. “We noticed a few years ago that there is no shortage of fungal genomes … functional interpretation is as tough as it has been 10 years ago,” he said. “We thought about reconstructing gene …

… rely on enzymes that have been evolving for billions of years. However, these enzymes are often loosely understood, … plant, fungi and animal. This analysis led them to identify 2,938 putative AT  genes. Within the AT genes identified … that even enzymes that evolved separately for billions of years have some common signatures of muli-substrate …

… expediting BGC and biosynthesis research.  Summary Over the years several secondary metabolites databases have been made …

Lentinula genus diverged roughly 28 million years ago, when the largest mammal ever, Paraceratherium, …

… that adapted to marine environments hundreds of millions of years ago.  The Impact Chloroflexota are bacteria that act …

… that helped plants conquer land over 600 million years ago. The Science By studying the genes of land plants’ … share key genes with land plants for making and modifying cell walls, a feature crucial for surviving on land. … the US National Science Foundation (NSF) CAREER award (DBI-1652164, 1933521), the Nebraska Tobacco Settlement …