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CRAGE-CRISPR combo helps further demystify biosynthetic gene clusters.  The Science Microbial … active secondary metabolites and helping them identify and describe the functions of the biosynthetic gene … highly regulated in bacteria, making it difficult to identify which pathway corresponds to which metabolite. Finding a …

… dwell in herbivore guts and help them digest their last leafy meal. In their evolutionary history, these fungi branched … proposal. The next step for the team was to try to identify what natural products the fungi were making. So, Trent … Contract Nos. DE-AC02-05CH11231 (JGI) and DE-AC05-76RL01830 (EMSL). CLS is also supported by a National Science …

Jarrod Chapman, developed a method to correctly identify polyploid subgenomes without needing to know the genomes … it’s hard to analyze. The ancestors are a bit hard to identify and there’s a small possibility that something could be … on this kind of analysis in more species, as well as modifying this method to study other types of problems …

… funded by the US-National Science Foundation grants OCE-0728391, OCE-0937404, OCE-1558795 to A-L.R, and OCE-2049478 and DBI-2047598 to K.A. We thank the Department of Energy …

Atlas in  Nucleic Acids Research . The project spans 15 years and involves more than 17 research groups. The team … Having a better handle on the gene function helps identify the molecular targets for plant improvement. … include six more species, so in total, we are looking at 18 different species, which included over 2000 RNA Seq …

… more than once, and these events took place a million years apart: the individual with a maternal  B. distachyon parent (D plastotype) some 1.4 million years ago (Mya), while the S plastotype was a more recent … anticipated with only minor gene loss even after a million years.” Reference genomes for  B. distachyon ,  B. stacei …

… a dark room with a flashlight, only able to clearly identify what falls within that single beam. When it comes to … but we knew the families,” Kyrpides said. Yet, “almost 20 years of metagenomic data and metagenomic analysis, and … might those ‘unknown unknowns’ hold?  The team started with 8 billion metagenome genes from IMG (the study also …

… in, on, and around the planet remain unknown. In recent years, advances in sequencing technologies and bioinformatic … Parks). In these springs, temperatures can reach as high as 80°C (~190°F), yet microbes thrive here. The communities in … diverse than those within more moderate ecosystems. A few years ago, a candidate bacterial lineage was identified from …

Unique Capability DAP-seq allows researchers to identify all the sites where transcription factors bind quickly … ENCODE project known as FUNCODE. “We noticed a few years ago that there is no shortage of fungal genomes … functional interpretation is as tough as it has been 10 years ago,” he said. “We thought about reconstructing gene …

… the simplest cotton genome ( Gossypium raimondii ) several years ago.   As well as the seminal Human Genome Project DOE …

… rely on enzymes that have been evolving for billions of years. However, these enzymes are often loosely understood, … plant, fungi and animal. This analysis led them to identify 2,938 putative AT  genes. Within the AT genes identified across …

… expediting BGC and biosynthesis research.  Summary Over the years several secondary metabolites databases have been made …