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… Danielle operates the single-cell genomics pipeline for JGI collaborators. This work combines custom flow cytometric analysis, cell sorting, genome amplification, PCR screening, and 16S …

… Vision  Lead genomic innovation for a sustainable bioeconomy. Mission  As a U.S. Department of …

… putida to break down biomass and help bring about a more sustainable, biobased economy. They conduct research at the …

… threads in the mix. But in the Petri dish, the thin vermicelli-like threads floating delicately above the leaf debris are revealed to be single bacterial cells, visible to the naked eye. The unusual size is notable … with its life cycle. For most bacteria, their DNA floats freely within the cytoplasm of their cells. This newly …

… a single experiment — and integrated these data with single-cell gene expression maps. Together, the scale of data … and fragmented genomic DNA, eliminating the need for living cells. This allowed researchers to map regulatory “switches” … in evolutionary conservation; and integration with single-cell RNA sequencing reveals how transcription factors …

… in her 2020 Nobel Prize in Chemistry. She then pivoted towards the future and shared ways that her team is looking … . Assaf Vardi , Weizmann Institute of Science One cell can change large-scale processes Keynote Talk Title: … of Science in Rehovot, Israel, where he studies single-celled algae in the ocean. “Although single-celled, …

… high throughput approach for isolating individual bacterial cells and amplifying their genetic material, thus bypassing … Microscale Applications group to operate a similar single-cell genomics pipeline that provides JGI users access to the … including those that require fluorescence activated cell sorting and non-standard molecular protocols.  Finally, …

… domain, looking for context clues that might point them toward the domain’s function. They found many instances of … structure of the protein related to its function inside the cell, Grosjean used the JGI-developed  guideRNA and Sequence …

… economic advantages for farmers concerned with improving sustainable soil management practices. Read the full release …

… Genomics, and led the computational efforts directed towards the sequencing, annotation, and analysis of three … evolutionary focus, his work on plant genomics is targeted towards the development of improved biofuel feedstocks and … Publications … Selected Publications …

… interested in harnessing the brown rot Serpula lacrymans towards breaking down plant mass for conversion to sustainable, alternative biofuels and bioproducts. This … Summary Unlike white rots, brown rots break down only the cellulose and hemicellulose, leaving the lignin behind. The …

… can support biological data analysis. It is a free, open source analytics platform provided to the …