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… as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my work, in … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… genome miners, and today we have Francisco Barona-Goméz, or Paco, as he prefers to be known among friends in … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

We should do some kind of special sound effect like a kazoo. DAN UDWARY: I do have some beeps and stuff that I can … is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… sustainability, and bioproducts. By sequencing and analyzing the genomes of these organisms, the program … algae, examining both natural populations and engineered strains. This approach allows for the identification of key … The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of …

… when I joined your lab as a postdoc, it was in Tucson [Arizona]. Which most definitely does not have an ocean. Brad: I … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… fosters team science and collaboration with partner organizations such as the DOE Systems Biology Knowledgebase and …

… especially when we start talking to people who specialize in that area. In this primer, we talk about my favorite … more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene …

… . One of them supports a project between JGI and LanzaTech, a Skokie, Illinois-based company that recycles … feedstock into valuable bioproducts, but many  Clostridium strains are difficult to engineer. Yasuo Yoshikuni and his … of complex pathways. The team will be working with LanzaTech to rapidly engineer a Clostridium strain for the …

… and then I switched to chemical engineering and realizing that wasn’t for me and eventually, I got to chemistry. … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… support open data and information sharing. We also recognize the need to have a limited and time-sensitive protection … are subject to a  two-year embargo starting at construct or strain delivery.  Detailed sequence information for constructs are made publicly …

… a month and a half later. In September, I went to a centralized computer room, because that was what existed back then, … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …