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… resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … and personnel resources for genomic research and sequence-based science.  Projects include de novo generation …

… locations.  One group investigated changes in protein sequences, while others analyzed single point mutations … Facility at Lawrence Berkeley National Laboratory, provided sequence resources — including the eelgrass genome assembly … evolutionary genomics of host–microbiome interactions in Zostera marina and other seagrasses). The work (proposal …

… embargo starting at construct or strain delivery.  Detailed sequence information and constructs are made publicly …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … And that’s what I really wanted to do. And that’s why I came back to academia. And I set that up. And we …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … that I never anticipated starting– that’s not why I came to the University of Utah– is looking at the … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to … between chemistry and sequence to get anywhere. Like that’s why I say the more you know, the more you know because it …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … had to scale also by orders of magnitude. And that’s why Satria figured out some new clever tricks to make an …

… DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … – how bacteria or other organisms communicate and how and why secondary metabolites are being produced in the … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … this and that. They’re doing all this 16S and I said, “Why don’t you just include the ITS too? It’s so easy to add …