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… on genomic science projects that address sustainable biofuel and bioproducts production, leveraging systems-based … biogeochemistry — questions of relevance to DOE’s Office of Biological and Environmental Research (BER) missions .  … All proposals will be externally peer-reviewed for scientific merit, DOE mission relevance, proposed data …

… about Antarctica, and we want to talk about molecular networking, because I really enjoyed the review that you wrote … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

Not one of our normal interviews, but instead it’s two interviews in one. My new co-host, Jackie Winter, has … is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … better to do it together, to join forces instead of to make two competing tools. If we had known about your tool, Dan, …

I’m interested in the world of natural products is also twofold but for different reasons to learn about how nature … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… on the way – I’m going to try to keep them coming out every two weeks for a while – so I hope you’ll be listening. But … already had a fermentation process with already engineered strains, but this was to further build on those to try and … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … today, run full-fledged marine chemical ecology programs. Two of the great students are in Georgia, in Atlanta, at … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… out, you probably want to go back and listen to the first two parts ( part 1 is here and part 2 is here ) so you … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

… at the University of Illinois at Urbana-Champaign. I had a two body problem, and it was a really great opportunity to … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… initiatives new to the JGI. Projects must be independent of ongoing JGI proposals, and lead PIs cannot have been lead … the foundation for a large-scale CSP proposal submission. Sequence requests should not exceed 3 Tb in total. Proposals … any time as brief white papers. Applicants may submit up to two proposals per year (but may be listed as co-PI on an …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … Takemura, whose voice you’ll hear in a minute – we work for the US Department of Energy Joint Genome Institute, or … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain …

… mining, and how we might start to better connect those two things, because I think that’s ultimately what needs to … Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …