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… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … of Life. We then investigate the coding potential to find novel functions that may impact microbiome structure and …

… be proposing a larger project that requires the work of two or more DOE user science facilities. That’s kind of out … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables … mass spectrometry-based methods to analyze metabolites from a wide range of biological and environmental samples — … and their hosts on ecosystems.   Environmental molecular network:   ENVnet   is a comprehensive, mass …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … scientific audience whereas now I’m sitting here with two people who know way more about natural products than I …

DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … often use primary metabolites as building blocks to produce novel molecules. And so we’ve got glycosides being made into …

We focus our efforts on integrating database mining and sequence design with scaling the production of large, … on developing methods for converting digital information from sequence databases into biotechnological or … applications.  We are interested in:  characterizing novel enzymatic activities using phylogenomic driven …

… regulation, and noncoding RNAs in microbiomes. The insights from this work have the potential to drive innovations in … most pressing challenges. … Exploration of phylogenomic novelty: Advances in metagenomic sequencing, assembly and … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… on the way – I’m going to try to keep them coming out every two weeks for a while – so I hope you’ll be listening. But … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We … secondary metabolism analysis and research as a driver for novel technologies that can serve all JGI users. Nigel has a …

QC Protocol DNA Extraction 101 : tips, kits, and protocols (from PacBio) Guidance for sample collection and storage (from PacBio) Best practices for High Molecular Weight DNA … pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

… at the University of Illinois at Urbana-Champaign. I had a two body problem, and it was a really great opportunity to … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… out, you probably want to go back and listen to the first two parts ( part 1 is here and part 2 is here ) so you … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …

… that got me into natural products to be truthful. So, well, two things. My PhD work was with a fungal pathogen called … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …