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… JGI serves more than 2,500 users that predominately come from the public sector: academic and government institutions … among members that catalyze data flows and promote novel data applications. As a large-scale data generator, … Our metabolomics platform delivers rich metabolite profiles from diverse biological and environmental samples by using …

… welcome back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. … And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… be proposing a larger project that requires the work of two or more DOE user science facilities. That’s kind of out … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … develops data science tools for workflow management and novel automations for DNA design, assembly and analysis … platform enables users to validate hypotheses generated from mining genomic data by designing and assembling …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … scientific audience whereas now I’m sitting here with two people who know way more about natural products than I …

… DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … often use primary metabolites as building blocks to produce novel molecules. And so we’ve got glycosides being made into …

… QC Protocol DNA Extraction 101 : tips, kits, and protocols (from PacBio) Guidance for sample collection and storage (from PacBio) Best practices for High Molecular Weight DNA extraction and quality control (from PacBio) 2) Review guidelines detailing quantity and …

… lot going on, so I took a little break, but I’m hoping that from here I can get back to a regular schedule. I’m going to … on the way – I’m going to try to keep them coming out every two weeks for a while – so I hope you’ll be listening. But … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… through analyzing and harnessing genomic information from plants, fungi, algae, non-medical microbes, microbial … in doing so enabled the JGI to be the first to publish the sequence analysis of the target chromosomes 5, 16, and 19, … and bioproducts. The JGI continues to receive its support from the Biological and Environmental Research program in …

… at the University of Illinois at Urbana-Champaign. I had a two body problem, and it was a really great opportunity to … The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain …

… genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables … mass spectrometry-based methods to analyze metabolites from a wide range of biological and environmental samples — … and their hosts on ecosystems.   Environmental molecular network:   ENVnet   is a comprehensive, mass …

… We focus our efforts on integrating database mining and sequence design with scaling the production of large, … on developing methods for converting digital information from sequence databases into biotechnological or … applications.  We are interested in:  characterizing novel enzymatic activities using phylogenomic driven …