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And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … –of getting rid of all the non-spore formers. And yeah. And streptomyces don’t like that. So you can really, really …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … DAN UDWARY: That’s weird. I hadn’t heard that before. Why is that? Why would that be the case? ALISON NARAYAN: …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … there you go. [laughs] ALISON TAKEMURA: All the more reason why it could have been inspired by Super Smash Brothers. DAN …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an ongoing … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … their abundance. It’s just that they’re less studied than streptomyces, the genus, right? Dan Udwary: Right. Kate … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … people who used to be exclusively working with bacteria and Streptomyces are now doing quite a bit of work with fungi. … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …