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And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … We can also genetically manipulate them. We can do strain improvements. We can do all sorts of things. So …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a … tells you what some of those design rules might be and constrains hypotheses that you can test about how to put things …

Developed in 2017, the PDT was established in part to help better-connect … feedstock into valuable bioproducts, but many  Clostridium strains are difficult to engineer. Yasuo Yoshikuni and his … be working with LanzaTech to rapidly engineer a Clostridium strain for the production of biofuels and bioproducts from …

Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the … And we’ve given them genome sequences of some of these strains. They’re not all Pseudonocardia . There’s other very …

… has been a pioneering effort in functional genomics since 2012, with a focus on addressing critical energy and … Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of … engineering traditionally utilizes a stepwise approach for strain development, requiring cycles of construct design, …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more … probably heard of the Salem Witch Trials back in the what? 15th, 16th century.  ALISON: Yeah, I lived in Massachusetts …

… (see Auspice Statement below) for the generation of sequence or metabolomic data, DNA synthesized, and any other … annotation, comparative analysis, and interpretation of sequence, metabolomics, and functional genomics data types … v/portal/lookup?keyName=proposalId&keyValue=XXXXXX&groupOnly=1&app=Info where XXXXXX is the WIP proposal ID. Example : …

… … DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I … already had a fermentation process with already engineered strains, but this was to further build on those to try and … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… genome program. And I’m a scientist here. And have been for 18 years. (LAUGHS) DAN UDWARY: All right. Easy start. What … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes … analysis of thousands of archaeal and bacterial type strains ( GEBA-type strains project ), the delineation of … al. (2017) Protein structure determination using metagenome sequence data. Science   355(6322):294-298 Paez-Espino D. et …

We focus our efforts on integrating database mining and sequence design with scaling the production of large, … developing methods for converting digital information from sequence databases into biotechnological or environmental …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … metagenomics. Nature Reviews Microbiology volume 20, 721–736 JC Villada, F Schulz (2022) The endosymbiotic box of … binning of a giant virus. mSystems. 5 (3) Schulz et al. (2018) Hidden diversity of soil giant viruses. Nature …