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… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … on Streptomyces clavuligerus , which was an industrial strain, a Streptomyces strain, the bacterium, that had been …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … on, first species, Salinispora tropica . And we isolated a strain that produced something extremely potent in killing … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Joint Genome … builds upon thousands of microbial genomes that have been sequenced by the JGI though not formally analyzed or … modules Currently 206 genomes have been selected with 11 published manuscripts published to-date Testimonials: …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … We can also genetically manipulate them. We can do strain improvements. We can do all sorts of things. So …

… algae, examining both natural populations and engineered strains. This approach allows for the identification of key … biocontrol agents dramatically affect plant health. The  1000 Fungal Genomes Project is a five-year project to sequence 1000 fungal genomes from across the Fungal Tree of …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a … tells you what some of those design rules might be and constrains hypotheses that you can test about how to put things …

… Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the … And we’ve given them genome sequences of some of these strains. They’re not all Pseudonocardia . There’s other very …

… stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more … probably heard of the Salem Witch Trials back in the what? 15th, 16th century.  ALISON: Yeah, I lived in Massachusetts …

… genome program. And I’m a scientist here. And have been for 18 years. (LAUGHS) DAN UDWARY: All right. Easy start. What … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… has been a pioneering effort in functional genomics since 2012, with a focus on addressing critical energy and … Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of … engineering traditionally utilizes a stepwise approach for strain development, requiring cycles of construct design, …

… DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I … already had a fermentation process with already engineered strains, but this was to further build on those to try and … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes … analysis of thousands of archaeal and bacterial type strains ( GEBA-type strains project ), the delineation of host-virus … al. (2017) Protein structure determination using metagenome sequence data. Science   355(6322):294-298 Paez-Espino D. et …