Search

… heard how a lot of us who work in fungal natural products, especially in the old days, saw how hard it was – it felt … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… operations, and scientific relevance and quality. Responsibilities of this board include providing technical … at the JGI; and overview of the Community Science Program (CSP). A crucial job of the committee is to take the input … and Environmental Research (BER) program, set the final sequence allocation for this program. …

The CSP New Investigator Call is for investigators and research … cannot have been lead PI on any previously accepted JGI CSP or FICUS proposal.   Competitive projects will provide … the foundation for a large-scale CSP proposal submission. Sequence requests should not exceed 3 Tb in total. Proposals …

… viral ‘dark matter’:   Viruses are abundant in the biosphere and influence microbial dynamics, evolution, and … comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

JACLYN WINTER: Dropping F bombs. We should do some kind of special sound effect like a kazoo. DAN UDWARY: I do have … is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… running in your family. Dan: So tell me about that. What sparked it? I mean, what made you want to work in natural … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… aflatoxin being a secondary metabolite from an Aspergillus species that is pretty toxic – can cause liver … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… that are known to be sources of secondary metabolites, like sponges were a really common source for people to try to … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… legal counsel representative). The User Agreement and corresponding Appendix must be signed and returned before work on … be notified by your project manager in the initial correspondence with you if the User Agreement and Appendix are … I request a culture/slant/DNA of an organism that has been sequenced at the JGI? … How do I check the current status of …

… and this will be episode 11. This continues our little sprint on genome mining. In the last episode , Alison and I … about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… good description of anyone because chemistry means a lot, especially when you’re working in natural products right. … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … Those are very– those are deserts. They’re very, very sparse areas. And we have certainly– when we first started …