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… Laboratory. Being a User Facility means that scientists from all over the world bring us big problems related to … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … ALISON: Hmm. It kind of – it’s kind of like I’m smelling bacterial perfume. I mean – but it’s purposeful so it’s some …

… such effort is targeted at environmental cells that are from candidate phyla, major branches in the phylogenetic … in 1985, which highlights our skewed understanding of microbial metabolism towards a minority of cultivated … is also reflected in the strongly biased representation of sequenced genomes in the public domain, the bulk of which …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … time called Genbiotics , which was a large program to find novel antibiotics. And this particular project focused …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… As a National User Facility, the JGI serves more than 2,500 users that predominately come from the public sector: academic and government institutions … among members that catalyze data flows and promote novel data applications. As a large-scale data generator, …

… DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … often use primary metabolites as building blocks to produce novel molecules. And so we’ve got glycosides being made into …

… Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… parameters driving virus:host dynamics in environmental microbial communities. This involves both experimental and … of phage and virus genomes have been assembled and reported from metagenomes, our understanding of the impacts of these … invaluable information on virus diversity and activity in microbial communities, however they can only provide a …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways … of the opinion that on the geological timescale, that most bacterial natural product systems evolved, you know, a …

… Lawrence Berkeley National Laboratory. The JGI consists of 225 researchers and support staff in the Integrative Genomics … through analyzing and harnessing genomic information from plants, fungi, algae, non-medical microbes, microbial communities, and other relevant organisms. We …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … in a microalgae. There were four genes there. Not like a bacterial gene cluster, but they were still clustered in the …

… lot of like synthetic chemistry effort to create a bunch of novel compounds that actually didn’t pan out. DAN: And there … able to explore DNA sequencing and actually get to the DNA sequence – sequences for the genes that code for the … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less …