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… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by synthesizing genes, pathways, and whole chromosomes for … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… datasets, particularly for uncultivated microorganisms, by sequencing large populations of bacteria and archaea in … resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, …

… hard it was – it felt kind of like training for a marathon by running at a high altitude! And a lot of us moved on to … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … genetic differences and then expanded on on that knowledge by doing a second postdoc with Yi Tang at UCLA and then kind … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… the foundation for a large-scale CSP proposal submission. Sequence requests should not exceed 3 Tb in total. Proposals … synthesis, metabolomics and analysis will be paid for by the Department of Energy’s funding of the JGI. There is … merit, DOE mission relevance , proposed data usage by the applicant/community, and track record of the …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … called Salinospora . This new genus was discovered by friends and colleagues at the Scripps Institution of … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… including a downloadable pdf of products categorized by Science Program.  … The majority of JGI projects come … work on your proposal may begin.  You will be notified by your project manager in the initial correspondence with … I request a culture/slant/DNA of an organism that has been sequenced at the JGI? … How do I check the current status of …

… merit, DOE mission relevance, proposed data usage by the applicant/community, and track record of the … synthesis, metabolomics and analysis will be paid for by the Department of Energy’s funding of the JGI. There is … must clearly demonstrate relevance and translatability to freshwater, coastal, or terrestrial systems. … All proposals …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … home. Or actually not my room, it’s the room of my little baby daughter, who inherited this room from her sister. And it … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… has been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… more about Tiny Earth and the JGI’s role in the project by watching Amanda Hurley’s presentation from the 2019 JGI … at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …