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Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … and their roles in the environment, can unlock new avenues for bio-based products and bioenergy crop … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

Below is a brief description of the process needed to prepare and ship samples for … sample QC requirements and protocols Obtaining DNA and RNA of suitable quantity and quality has been the rate-limiting … pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … right. So I did a PhD in microbiology at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so …

Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society for Industrial … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… other things. And we know lots more about microbiomes and symbionts that live with other organisms, and often it’s the … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… and other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … A global metagenomic map of urban microbiomes and antimicrobial resistance. Cell . 184(13):3376-3393 Almeida A, et … al. (2017) Protein structure determination using metagenome sequence data. Science   355(6322):294-298 Paez-Espino D. et …

… the user programs at the JGI, and I’m also the head of the microbial genome program. And I’m a scientist here. And have … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the … And sometimes, in terms of biological activities– like antimicrobial or something– sometimes a little difference is …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … IMG kind of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial …

Micro-Scale Applications group explores the genetic makeup of natural microbial communities using a variety of cutting-edge … access to cutting-edge cell sorting, DNA amplification, and sequence analysis to recover the genomes of uncultivated …

… — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing data for synthesis. This agreement, required … address the DNA Synthesis program. When fully executed, the new User Agreement will replace the active version. For …