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… and other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … advances in management, processing and visualization of “big data,” and artificial Intelligent/machine learning … breakthrough discoveries and catalyzing a major transition of biology into data science.  Research in the Kyrpides …

… Micro-Scale Applications group explores the genetic makeup of natural microbial communities using a variety of cutting-edge approaches.  Our group also seeks out new … the quality of single-cell genomes and directly link functional information with individual cells. Research Team  …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… as user facility that aims to provide access to state-of-the-art DNA synthesis and assembly technologies to the … We focus our efforts on integrating database mining and sequence design with scaling the production of large, … design principles for successfully engineering pathways to function in heterologous hosts, by combining combinatorial …

… Microbes drive critical ecosystem functions and affect global nutrient cycling, however they … group aims at improving our collective understanding of ecological and evolutionary parameters driving virus:host … involves both experimental and computational exploration of uncultivated viral diversity, characterization of …

… stewardship expertise and infrastructure enable a broad community of scientists and engineers to leverage our data to develop new algorithms, models and tools in support of DOE mission priorities. Data discoverability and … Download plant, algal, fungal and microbial genomes and metagenomes — top-quality genomic data, open to all …

… work with undergraduates in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Joint Genome … builds upon thousands of microbial genomes that have been sequenced by the JGI though not formally analyzed or … necessary to extract meaningful biological insights from sequence data, employing IMG data and tools for comparative …

… Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and … their potential applications in the bioeconomy including biofuels, biochemicals and sustainable agriculture. …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that really got …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … the end of last year. Dan: So these are going to be seaweed metagenomes? You’re sequencing everything? Brad: Metagenomes …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were and how they function. So I worked on a team at the Broad that was … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … ALISON: Hmm. It kind of – it’s kind of like I’m smelling bacterial perfume. I mean – but it’s purposeful so it’s some …