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… … Download plant, algal, fungal and microbial genomes and metagenomes — top-quality genomic data, open to all … integrated context. IMG/M provides tools for analyzing the functional capability of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

… as user facility that aims to provide access to state-of-the-art DNA synthesis and assembly technologies to the … We focus our efforts on integrating database mining and sequence design with scaling the production of large, … design principles for successfully engineering pathways to function in heterologous hosts, by combining combinatorial …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … the end, we took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… of host-virus interactions, the exploration of the functional dark matter as well as the development of novel … al. (2021) CheckV assesses the quality and completeness of metagenome-assembled viral genomes. Nature Biotechnol . … al. (2017) Protein structure determination using metagenome sequence data. Science   355(6322):294-298 Paez-Espino D. et …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

Secondary Metabolites Program focuses on the exploration of secondary metabolites across bacteria, fungi, algae and … experimental approaches to explore the synthesis and function of these biologically significant compounds. By … computational analyses of BGC size and complexity, BGC sequence composition, metabolic similarity & compatibility, …

… work with undergraduates in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Department of … datasets encompassing >150,000 isolate genomes, 230,000 metagenome-assembled genomes (MAGs), and 40,000+ metagenomes …

… at genomes and seeing where the really hard things to sequence were, and wondering what those … what those were and how they function. So I worked on a team at the Broad that was … functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that really got …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … the end of last year. Dan: So these are going to be seaweed metagenomes? You’re sequencing everything? Brad: Metagenomes …

See below for examples of successful Letters of Intent to our Community Science Program Large-Scale Call, as well as successful submissions to our CSP New Investigator, CSP Functional Genomics, and Facilities Integrating …

… the JGI plays a leadership role in enabling the frontiers of research related to DOE’s missions in bioenergy, carbon cycling and biogeochemistry. In complement to the Community Science Program, JGI researchers drive innovations … the boundaries of the Plant, Fungal, Algal, Microbial, Metagenome, Metabolomics, Secondary Metabolites, and DNA …