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… approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop computational approaches to … Our research focuses on the assembly of metagenomic sequence data into microbial genomes, which is of … potential applications. By recovering population genomes from metagenomes, we gain insights into microbial …

… systems. No one was, at that time, really working with microbes from the ocean. So I felt there was a wonderful … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … a nice example of going from a whole community with many microbes, hundreds of gene clusters, and then being able to …

… This time, we’ve got a great interview with Ben Shen, from the Scripps Research Institute in Jupiter Florida. This … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… to identify over 27,000 microbial genes. The data from that study is now used across California State … of a course-based undergraduate resource experience. Hear from CSU San Marcos Professor Matt Escobar and UC Davis … of the JGI User Executive Committee, on how that study went from the lab to the classroom. …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… The ranked proposal list, along with a recommendation from management at JGI and the other participating … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… processes, development of high performance plants and microbes, and understanding microbiome interactions. The  … insights into how small molecules function within plants, microbes, and ecosystems. Identifying and analyzing primary … mass spectrometry-based methods to analyze metabolites from a wide range of biological and environmental samples — …

… activity. So the chemistry and function really of those microbes that live there.  And in our work we’ve determined … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … with any kind of gene cluster identification, doing it with sequence alone you have to have some kind of a template to …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … ecology community to be able to better predict how their microbes are interacting with each other from sequence …

… what’s important in terms of the chemistry produced by microbes. And by what’s important, I mean, like, where … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …