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… where I was a graduate student. Aflatoxin, of course, is a fungal natural product which is a liver toxin when humans … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh … DAN UDWARY: That’s weird. I hadn’t heard that before. Why is that? Why would that be the case? ALISON NARAYAN: …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … not enough time and money. I mean, we have a huge marine fungal project in collaboration with Bill Fenical at … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have … of weird growths on livestock due to you know, bacterial or fungal infections. Yeah, okay. So he identified these things …

… other plant-associated fungi. Their analysis identified fungal gene families that help determine if these fungi act … partnerships. To learn more about these other plant-fungal relationships, an international team led by graduate … from natural Arabidopsis populations around Europe. The JGI sequenced and annotated 41 fungal isolates from the …

… drive innovations that cross the boundaries of the Plant, Fungal, Algal, Microbial, Metagenome, Metabolomics, …

… in fungi. The Science Changing an A, C, T or G in a genome sequence can lead to changes in protein structures and … on the largest analysis of 5mC distribution across the fungal tree of life to date, involving more than 500 species … that can move to another location in the genome. Many plant pathogens such as the fungi that cause poplar leaf rust, are …

The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … students, we obviously can't put any antibiotics or antifungals in there. So they get just a smattering. JACKIE: …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … future. So, then we were using these probes to look at host pathogen interactions mostly with like enteric bacteria. And …