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… to request the capabilities and expertise of multiple DOE National User Facilities in one research proposal.  … FICUS call with EMSL begin with a Letter of Intent (LOI) from a researcher, briefly describing the project … samples of the spatial, temporal, taxonomic (environmental, microbial, plants, invertebrate, and vertebrate), and …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … living there. So we’re looking at how they adapt to these extreme environments. And then can we use that, for example, … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… bioenergy and environmental problems.  The mission of the National Energy Research Scientific Computing Center ( NERSC … The ranked proposal list, along with a recommendation from management at JGI and the other participating … … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on …

… two billion years ago. A team of researchers set out to Yellowstone National Park to study how cyanobacteria are living, communally, in microbial mats. Along the way, they’ve encountered …

… we have our conversation with Professor Alison Narayan, from the University of Michigan. I hope she’ll accept this … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … the tetrapeptide, that's a 12 membered ring. And there's extreme ring strain in 12 membered rings. You also have to …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … tropica . And we isolated a strain that produced something extremely potent in killing cancer cells. Well, chemically, … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

QC Protocol DNA Extraction 101 : tips, kits, and protocols (from PacBio) Guidance for sample collection and storage … carrier’s tracking information. JGI Shipping Checklist International Shipments (For shipping packages internationally — … pipelines.  You will receive automated emails as raw sequence data becomes available, and as analysis is …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language of microbial cell-cell communication. And he told us about his … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. …

… the user programs at the JGI, and I’m also the head of the microbial genome program. And I’m a scientist here. And have … at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop … of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic properties … within those genomes. Our aim is to more fully capture microbial and viral diversity, leading to a better …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … IMG kind of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial …