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… Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… Apple Podcasts or wherever you’re getting this and tell me why you’re listening. DAN: But, now, here’s Natural Prodcast … took a long time for .. I mean, structural elucidation was extremely difficult before the advent of two dimensional NMR … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … genomic revolution, to me, as a natural part chemist for microbial natural product, is that I love microbial natural …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … living there. So we’re looking at how they adapt to these extreme environments. And then can we use that, for example, … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… to request the capabilities and expertise of multiple DOE National User Facilities in one research proposal.  … FICUS call with EMSL begin with a Letter of Intent (LOI) from a researcher, briefly describing the project … The ranked proposal list, along with a recommendation from management at the JGI and the other participating …

… including fungal and bacterial symbionts, detrimental microbial pathogens, and associated viruses that all … how plants self-organize, influence, and are influenced by microbial partners. We use a variety of genomics-powered …

… bioenergy and environmental problems.  The mission of the National Energy Research Scientific Computing Center ( NERSC … The ranked proposal list, along with a recommendation from management at JGI and the other participating … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on …

… The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … the tetrapeptide, that's a 12 membered ring. And there's extreme ring strain in 12 membered rings. You also have to …

… parameters driving virus:host dynamics in environmental microbial communities. This involves both experimental and … of phage and virus genomes have been assembled and reported from metagenomes, our understanding of the impacts of these … invaluable information on virus diversity and activity in microbial communities, however they can only provide a …

… we have our conversation with Professor Alison Narayan, from the University of Michigan. I hope she’ll accept this … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… two billion years ago. A team of researchers set out to Yellowstone National Park to study how cyanobacteria are living, communally, in microbial mats. Along the way, they’ve encountered …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … tropica . And we isolated a strain that produced something extremely potent in killing cancer cells. Well, chemically, … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …