Search

… the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very … product chemistry? BEN:  Yeah. So, I was trained as a plant natural product chemist. When I first started in …

… with a contract manufacturer to actually have them build a plant for production and fermentation and transfer that … risks that would lead to things like leakage of organism, plant, product, et cetera. But yeah, I think it allowed us … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

Uncovering associations between plant roots and fungi that can help or harm plant host health. The Science Researchers compared the … from natural Arabidopsis populations around Europe. The JGI sequenced and annotated 41 fungal isolates from the …

… the special, natural chemical compounds that you find in plants, fungi and bacteria, basically all living things. … stories about natural products, so you can get a feel for why I think they’re so important, and we’ll start to explain … more about some of the background and sort of the reasons why we want to do this. And also to provide a little more …

… of energy and nutrient exchange, as well as microbial and plant responses to environmental changes. With advanced mass … biogeochemical processes, development of high performance plants and microbes, and understanding microbiome … to gain insights into how small molecules function within plants, microbes, and ecosystems. Identifying and analyzing …

… at JGI start with sequencing, but where else did those sequences go? Like, what are the other scientific tools we … our eukaryotic genomes, all our eukaryotic genomes. Fungal plant, algal genomes, a lot of effort goes into generating … that describe the work. In general. Scientific merit and why it’s important. The DOE mission is one of these …

… and ergot alkaloids come from fungi, and Taxol from plants. Plants, fungi, bacteria, archaea, they all have … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… of their synthases so that we can start to use the DNA sequence to predict or just understand better the language … your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … DAN: Almost like you know that there is. AARON PURI: It’s a planted question Dan. Yeah. So overall I think what we’re …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … design tool  … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from … of microbial communities based on their metagenome sequence, in the context of reference isolate genomes …

… chemicals that are coming out of organisms, whether it be a plant or from the bottom of the ocean, from a sponge, or a … then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of … decomposition, CO2 fixation, redox reactions, and plant metabolite biosynthesis, synthesizing and … Science Group supports researchers exploring how to convert sequence into functional assessments. The team has a …