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… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … that I never anticipated starting– that’s not why I came to the University of Utah– is looking at the … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …

… embargo starting at construct or strain delivery.  Detailed sequence information and constructs are made publicly …

… A fungus relies on bacteria to regulate key components of its … have evolved from a parasitic interaction with their soil fungus host, Rhizopus microsporus . Researchers found that … with the fungi and bacteria, while the DOE JGI team sequenced and annotated a host genome (Rm ATCC 52813) as …

… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … I’ve seen you give a few talks on that. Can you tell us why cone snails are so cool? ERIC:  So cone snails are … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… from similar organisms, researchers have gained insights on why the dry rot ( Serpula lacrymans ) is so destructive in … and bioproducts. This study lends insights on how the fungus has responded to manmade changes in its ecological … Serpula species, S. himantioides from Europe, that was sequenced and analyzed by the JGI. The researchers found …

… about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … had to scale also by orders of magnitude. And that’s why Satria figured out some new clever tricks to make an …

… first time, a team analyzes the transcriptomes of a lichen fungus and alga to understand their partnership more … actually comprised of two (or more) participants. One is a fungus (usually belonging to the ascomycetes, one of the two … nitrocellulose filters in Petri dishes. The scientists also sequenced the fungus and photobiont’s genomes and compared …

… comprising the largest public collection of plasmid sequences identified from genomes, SAGs, MAGs, metagenomes …

… capabilities support researchers exploring how to convert sequence into functional assessments. This is done by … BOOST provides a suite of tools to automate sequence design for assembly by Gibson, Yeast recombination …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … And that’s what I really wanted to do. And that’s why I came back to academia. And I set that up. And we …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against … get made fun of by my now-wife, because she was wondering why it is that we needed to produce more toxins in the lab …

… in the analysis and publication of the claimed genome sequences. This opportunity, provided by the Joint Genome … builds upon thousands of microbial genomes that have been sequenced by the JGI though not formally analyzed or … necessary to extract meaningful biological insights from sequence data, employing IMG data and tools for comparative …