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… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… Leveraging massive comparative genomics to decode millions of mystery genes and lay a future-ready foundation     Over … fungi remain largely mysterious. Only about 200,000 fungal species have been named. Among those sequenced, roughly half of all genes have completely unknown …

… for researchers to request the capabilities and expertise of both national user facilities in one research proposal.  … challenges in the sourcing, recovery, and utilization of critical minerals and materials. The proposal submission … Access to the Molecular Foundry and use of JGI capabilities is free. The JGI supports remote users. …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial … and are influenced by microbial partners. We use a variety of genomics-powered tools to study this complexity, …

… Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society for Industrial … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… here today, and we wanted to talk to her about a whole list of things. So we have a Scripps background shared together, … Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …

… analysis techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … associated with microeukaryotes, enhances our understanding of terrestrial biogeochemical cycling and inter-organismal … microorganisms, by sequencing large populations of bacteria and archaea in their natural environments using …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … live in the root nodules of plants. And these guys were sequenced, and you can see that different Frankia have …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … about the basics of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary … biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean …

… Hey, everyone! Welcome to the “Self Promotion Episode” of Natural Prodcast. A little bit of a bonus episode, since … is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a …