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… you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … one of the most common animals in the ocean. They’re really species-diverse. I lost track actually of the number. But, … turns a peptide, for example, from a disordered sequence into an antibiotic that kills bacteria through a …

… resequencing, RNA sequencing and epigenomics. Expansion of sequence space:  The JGI generates reference genomes from diverse bacterial and archaeal lineages to improve … annotations, and function distribution. These are derived from isolates and single cells. This effort uncovers novel …

… aflatoxin being a secondary metabolite from an Aspergillus species that is pretty toxic – can cause liver cancer and … out introns and dealing with, you know, weirdness in the sequence. You know, some clusters are not clustered…   … it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk …

… culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … methicillin-resistant Staphylococcus aureus . Can you share why finding treatments for these microbes is so important? … of infectious or inflammatory disease and these same species are being used not just by one generation but by …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … are novel. I mean, we have Streptomyces , but they’re new species. And they have very similar [genomes] to other …

… drive resilience when salinity fluctuates. The Science The Arctic microalga Plocamiomonas psychrophila can thrive in … Biology article highlights how one microalga collected from water on the ice surface handles such fluctuations. P. psychrophila is a species of Pelagophyceae, a microalga shown to thrive in …

… then genomics happened. Dan: Yeah, I did my first genome sequence with you. Brad: That’s right,  Dan: JGI did it in … us on that. You know, as an added benefit, the S. tropica species also makes an anticancer agent that today is in … working with you, Dan, on this one, and we said, “Well, why don’t we have you know, the bioinformaticians go against …

… The ranked proposal list, along with a recommendation from management at JGI and the other participating … For sequencing projects, once work is under way, raw sequence data is released to NCBI’s Sequence Read Archive on a regular basis, in accordance with …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … ecologists that they needed to consider chemical impact on species interactions, communication, that kind of thing. But … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… Duncan: Yeah. I love actinomycetes. Dan Udwary: Tell us why. I mean, I know, but I think– Alison Takemura: I want to … Right. Kate Duncan: And Pseudonocardia . And we’ve got new species which we’re currently in the process of almost finished characterizing them. We’ve got genome sequences, which are just incredible. We’ve looked at the …