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Bill is a pioneer of marine natural products, getting into the ocean and looking for molecules from the very … our ability. And ultimately we went through a whole lot of different processes with plants and animals, really, all … that the molecules out there would be toxic to cancer cells. And that started something big. Because at that time, …

… episode with her in the near future where we can dive into that. And I’m also dying to talk in more detail about … Yeah, well, there’s a lot of– there’ s a couple of different schools of thought with that. So some people are … a single cell level against cell lines and against primary cells isolated from patients up to 12 markers at a time. And …

… marine natural products chemist, Richard Moore, and get into seaweed, robots, algae, and biocatalysis — and he makes … him? I know a lot of people sort of veer off and go into different directions. Brad: Absolutely. You know, my father … or they can store that chemical – or they can store the cells, as well. And so we’re hoping initially to be able to …

… that a lot of people want to answer again from a very different standpoint or from very different angles, right? … than it is now. Or a little more– yeah, put more rationale into drug discovery by knowing what these things actually do … even in primary metabolism or in certain snips of viruses or something. I don’t know. Then I think making sure …

… that we’ve had on this podcast, the idea of taking all the different natural products data that there is and putting … question. Kate, can you tell me the story of how you got into secondary metabolites? Kate Duncan: So I always liked … spec– but I find it really interesting to sort of compare, conceptually, that data with genomics and the kind of things …

… also, I thought you were a good representative of maybe a different career trajectory than we sometimes see… MARC: … So maybe we could start with that background – what got you into secondary metabolism, besides being forced to work with … does it take to become a hub? MARC: We’re still trying to figure that out. I mean, we’re still quite new. I joined as …

… with microeukaryotes. The program also studies giant viruses. Key research areas include terrestrial … distribution. These are derived from isolates and single cells. This effort uncovers novel genes, protein families, … interactions: In an effort to gain insights into the interactions between microbial organisms and how …

… are you?  MARCY: Am fine. I live in a pandemic so I’m no different than anyone else.  DAN: Yeah. I mean fine in … a master’s in plant ecology. And that masters helped me to figure out that I didn’t really want to study plant ecology– … work we’ve determined that the ANMG deposits those bacteria into the jelly coat of the eggs. And so these eggs are laid …

… can visit the Products & Offerings section of our website for more details, including a downloadable pdf of products … request a JGI Single Sign On account at https://signon.jgi.doe.gov . This account can then be used to submit proposals, … ) Metagenomes and Single Cells: IMG/M   (citation: …

… basic ideas of the science of natural products, and we dive into the very early history of the field. If you continue … cell.  DAN: It depends on lifestyle. So there are lots of different organisms that produce secondary metabolites for … like, you know, like an organism. They have specialized cells and the ecology there is really fascinating, probably …

… on to work in simpler systems, like bacteria, where we figure we can make more progress faster, which is sometimes … amino acids it has access to, which can be really weird and different, and makes for lots of variety in chemistry. The … with a ribosome. Then, some other enzymes chop the protein into smaller pieces, and other enzymes might make other kids …

… to completion of standard analysis.  Raw data is provided for all sequencing products below. In addition, JGI will … small genes assembled to less than 5kb in length, cloned into vector of choice Glycerol stock of sequence verified … microbial aggregate, or a specific subset of free-living cells. Extracted DNA may be amplified using whole-genome …