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… We also talk about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an … unpalatable. And we know that this is one of the major adaptations in the ocean. So it took a while to convince … in the ocean in terms of what these naysayers had said– (MOCK TONE) “nothing new there!” Well, we started finding …

… been the main driver for secondary metabolism drug discovery. Because we always need new antibiotics. We need new … found in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you … Catalog of Earth’s Microbiomes. Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, …

… cell sorting, DNA amplification, and sequence analysis to recover the genomes of uncultivated microbes. We also apply …

… went on to work at a groundbreaking company in the early 2000s called Ecopia, which was a very early genome mining … and he’s doing some amazing research in and around drug discovery, which includes screening methods, genome mining in … on many areas of natural products biosynthesis and drug discovery. If you enjoy the interview, I’d encourage you to …

… Notice Effective July 27, 2026, the JGI will move to a new login service, requiring the … IMG , GOLD and others for data annotation and submission Tracking, monitoring and expediting laboratory processing …

… natural products by starting out in synthesis and then discovering more-- [LAUGHS] I don't know, practical or … 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY PARKINSON: Very, very-- … receptors. And so they were originally, I think, discovered in E. coli, but we can utilize blast searches or …

… something you’re interested in. OK. I think that should cover most of the government acronyms. You’re on your own … transcripts and more information about all of the topics we cover. OK. Long intro today. We’ll have two discussions. … We don’t want to get a proposal that’s just asking for 20 microbial genomes. That is not a good fit for our annual …

… Our research is focused on the discovery and characterization of novel bacterial, archaeal and … viral complexity and evolution Our research focuses on discovering and characterizing giant viruses, which possess … analyze large-scale biological datasets. This work helps uncover patterns and relationships in complex genomic and …

… research by then-Biosciences scientist Diane Dickel in 2017. In 2019, plant single-cell methods were officially called out …

… in this hypersaline environment, which can range from 8% to 28% salinity. We have toxic metals, so these concentrations … natural products, and especially if you’re in the drug discovery angle, is to look in industry. But you’re a … in the ’50s and ’60s of the golden age of antibiotic discoveries. Everything that we’re finding seems to be a new …