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… the user programs at the JGI, and I’m also the head of the microbial genome program. And I’m a scientist here. And have … We don’t want to get a proposal that’s just asking for 20 microbial genomes. That is not a good fit for our annual CSP … 100 kb versus 500 kb. In the lab, they’re going to do the whole set at one time. So it’s better to have really more, …
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… got Kate here today, and we wanted to talk to her about a whole list of things. So we have a Scripps background shared … And sometimes, in terms of biological activities– like antimicrobial or something– sometimes a little difference is … of new chemistry, and we want to understand the antimicrobial-resistant era, we need new chemistry. If we want …
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… right. So I did a PhD in microbiology at MIT, and I studied microbial ecology. I studied Vibrio species in the ocean, so … they figured out that they could culture the plant cells and produce enough that way in really large like 7500 … We’re looking at a schematic of different pathways in a microbial cell, it looks like. It could be a eukaryotic …
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This is done by synthesizing genes, pathways, and whole chromosomes for bioenergy, nutrient cycling and …
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… before. DAN: Yeah, yeah, fun stuff. MARC: And we call that whole thing, the “chemistry hub”, and that’s centered right … Canada. I just got back from a conference in Canada on antimicrobial resistance sponsored by the Garner foundation. And … so I’m you know, I’m a little bit familiar coming from a microbial ecology background myself, but not to this degree. …
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… quantities of DNA derived from individual environmental cells. The proof of principle study built off earlier … and offered a way for researchers to study the planet’s microbial diversity, much of which remains unknown and … the JGI and Bigelow Lab led to the identification of key microbial culprits in carbon fixation in the dark ocean. …
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… went on to advance basic science by sequencing scores of microbial species as well as several model organisms and … behavior of microbiomes and manipulate them to facilitate microbial solutions to challenging environmental … and bioproduct development. Develop an understanding of microbial and fungal metabolism necessary to …
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… at a time when they would do one genome at a time. And the whole purpose of that was that it was one of the first … are familiar with JGI’s IMG data portal , the Integrated Microbial Genomics, there was a subsection of that called … and they used that on all of IMG’s genomes. But IMG is microbial genomes — mostly bacteria and archaea. And we knew …
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… systems to express BGCs that alleviate the constraints of cells and allow for substrates to be directed towards …
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… identifying genes to that toxin, but it’s opened up this whole area of environmental health that we’re now working … or they can store that chemical – or they can store the cells, as well. And so we’re hoping initially to be able to bring those cells back and be able to correlate chemical to genes. We’re …
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Metagenomic datasets could help map out microbial diversity hotspots Over the past few decades, … in sequencing technologies have led to an abundance of microbial genomes becoming available to the global research … of the urgency to cultivate new microbial species.” Targeted Explorations for Understanding the Microbial World …
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