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… a method that allows researchers to quickly modify diverse bacterial genomes. In 2019, the JGI’s Yasuo Yoshikuni and … example, the JGI first used CRAGE to engineer domesticated bacterial strains with novel biosynthetic gene clusters … molecules of value to both human and ecosystem health. But bacteria often fail to express their BGC molecules in the …

… flagella in an unexpected place: hot spring-dwelling bacteria from the phylum C hloroflexota . Research shows … of millions of years ago.  The Impact Chloroflexota are bacteria that act like tiny natural engineers with special … and recycle carbon. They were part of an ancient lineage of bacteria to migrate from oceans and colonize land. …

… been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … lot of the natural products field is based on, you know, in bacterial investigations. You’ve spent your whole career as … it because of the complexity. They’re more complex than bacteria. Not that bacteria aren’t complex themselves. But a …

… 11, 2022, in Cell Genomics , the team focused on Actinobacteria ( Actinomycetota ), a group of bacteria with diverse metabolic activities. Found in marine and terrestrial environments, actinobacteria play roles in both the carbon and nitrogen cycles, …

… chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your crazy Aunt … I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we didn’t get into secondary metabolites … a chemical compound called geosmin that’s produced by soil bacteria that live all over the place. So that smell of rain …

… colleagues. Aaron is doing some cool stuff with cool bacteria that I’m fascinated to learn more about. He works … with methylotrophs, which are a group of carbon-fixing bacteria that I would say are are still fairly unexplored in … look at host pathogen interactions mostly with like enteric bacteria. And I really fell in love with the bacteria part …

… and comparative analysis of thousands of archaeal and bacterial type strains ( GEBA-type strains project ), the … genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea.  Nature Biotechnology  35(8):725-731 … Mukherjee S, et al. (2017) 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree …

… a check-up on me. And I wonder how that intersects with bacterial bioprospecting that is often done, where we’re … we don’t always know necessarily or pay attention to where bacteria come from. And do people even know that the bacteria are there? They haven’t been used as medicines. But …

An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria Check out the agenda for the JGI’s 2021 Annual …

… find, things that are of interest. And usually, in terms of bacteria and secondary metabolism, those things that we want … We need treatments for humans. And it just so happens that bacteria make a lot of the kinds of molecules that humans … things that are important in their own environments. Like, bacteria make antibiotics in order to challenge or kill off …

… origin is around 30,000 from fungal, and a 40,000 from bacteria. Okay? And among the 40,000 from bacteria, there’s around 20,000 from the Actinomycetes. So, … this collection in total contains approximately 100,000 bacterial strains, and a hundred thousand fungal strains. …

… viral infection cycle in wild populations of green sulfur bacteria with long standing virus-host interactions. ISME J. … et al. (2019) Cryptic inoviruses revealed as pervasive in bacteria and archaea across Earth’s biomes. Nature …