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… Dan Udwary: Hey everybody! Welcome back for Natural Prodcast episode 17. The guest we have this week … and other natural product libraries, so not relying on single crystal X-ray diffraction, but looking actually at … on plant natural products. Rich, rich in bacterial and marine stuff. So we need more people annotating. It will …

… genome miners use, including antiSMASH, MIBiG, and newer efforts, like BiG-scape and BiG-SLiCE, and now the BiG-FAM … of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial genomes. And … sometimes correlated or anti correlated, also with other cellular functions in the same and as it was other bacteria …

… The CSP Functional Genomics call is to enable users to perform state-of-the-art functional genomics research and to help them translate genomic … All proposals will be externally peer-reviewed for scientific merit, DOE mission relevance , proposed data … of insufficient quality or quantity will preclude approval for processing. …

… Takemura, whose voice you’ll hear in a minute – we work for the US Department of Energy Joint Genome Institute, or … that might need special technology for DNA sequencing, genomics, metabolomics, and synthetic biology, that maybe … great conversations that we’ve already recorded with some excellent scientists, and that’s probably how we’ll continue …

… Mexico, and an incredibly bright guy who’s been thinking for a long time about the evolution and natural products … I think the important thing to remember is that, thanks to genomics, we now know that it is very hard to find stuff … for example, in terms of the stereochemistry, such that single changes can lead to a particular high activity …

… can visit the Products & Offerings section of our website for more details, including a downloadable pdf of products … come from the user community. Find out about JGI’s calls for proposals , and submit your proposal online using the Work Initiation Process (WIP) interface.    For commonly asked questions about JGI’s proposal calls and …

… quantities of DNA derived from individual environmental cells. The proof of principle study built off earlier … and finished genome derived from an uncultured bacterial single cell – a symbiont of the green sharpshooter. In 2012, … in carbon fixation in the dark ocean. Combining single cell genomics and synthetic biology, a team studying microbial …

… and SIO. Oh, I should say what those are. Brad: What’s SIO, for all those listeners out there? Dan: Scripps Institution … the mid-late ’80s. And at that time, you know, it’s before genomics existed. This is before we’re even thinking of … of, better understand fundamentally what’s going on in the cell as it responds to its ocean environment. And as we …

… are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and … are influenced by microbial partners. We use a variety of genomics-powered tools to study this complexity, including single-cell and spatial transcriptomics barcode-based …

… community as a user facility pioneering functional genomics to solve the most relevant bioenergy and … discovery at the DOE Office of Science through high performance computing (HPC) and data analysis.  The DOE Systems … the Letter of Intent; rather proposals are submitted in a single step. …

… Minerals and Materials call represents a unique opportunity for researchers to request the capabilities and expertise of … The program seeks research proposals that integrate genomics with nanoscale science, accelerating discoveries and developing transformative bio-based technologies that address challenges in …

… discoverability and accessibility are critical requirements for amplifying the JGI’s impact. Data generated from a single investment will be reused for further science.  Notices Data Portal files will be … researchers. Book a session via the appointment calendar for technical help, feedback or a guided walk-through of the …