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… it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … everything is funding, right, isn’t it? I thank JGI for sequencing a lot of fungi. But the thing with them – to get … sequence is really cheap. I’ve got colleagues that are sequencing dozens and dozens of fungi, mostly coming out of …

… which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … it was a big deal. And you really had– I mean, the whole sequencing endeavor, had a cost, how much blood, sweat, and …

… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … that I never anticipated starting– that’s not why I came to the University of Utah– is looking at the … to grow. If you hear Nigel talk, he is very interested in sequencing a lot more natural product-heavy culture …

… biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … gene clusters. And I had heard the first rumors of people sequencing like these enormous numbers of genomes, like 20 … Dan Udwary: Very helpful, yes. And in that same sort of leapfrogging of data generation to data storage, now– well, …

… For accepted proposals, sequencing, synthesis, metabolomics and analysis will be … with DOE mission-relevant projects that call for expansive sequencing, synthetic biology, and metabolomics capabilities … Letters of Intent. Proposals may include synthetic biology, sequencing, and metabolomics. Proposals may include …

… the Broad that was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods … So you were saying, Mark, how the DNA that was breaking the sequencing from really being functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … technology.] BETSY PARKINSON: OK. DNA affinity purification sequencing. And so the way this essentially works is you … at the college level. So-- DAN: Yeah, for sure. And JGI is sequencing quite a few of the things that end up-- BETSY …

… resources empower students through isolation and genome sequencing of new fungal species.  Students collect fungi, … into iNaturalist. Myco-Ed has:  ~50 lineages selected for sequencing 16 genomes released 20 members from 15 … laboratories with minimal overhead (cost of media, ITS sequencing and tissue preparation), allowing participation …

… community at large with access to high-throughput sequencing, synthesis, and metabolomics at the JGI for … based on their DOE relevance.  For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … really exciting work on figuring out how to get genomic sequencing data for the fungus garden because it’s more … in this project, the interaction with JGI was really around sequencing for, I think, for the fungus garden and some of …

… to DOE mission is appropriate. For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … JGI and this was before they were integrated. So I thought, why not feed it in there. And I went to group meeting and … AARON PURI: Yeah. No, you’re exactly right. So you can see why these are tightly regulated. DAN: For sure. For sure. …