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… organism are proteins, which are made up of chains of amino acids. “Peptide” is just another word for a small protein. … you maybe explain what’s going on with their biology and why they’re so important to natural products? ERIC:  Sure. … took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  DAN:  And …

… Institute is to serve the scientific community as a user facility pioneering functional genomics to solve the most … by JGI staff as well as staff at the other participating facilities. Reviewers consider technical feasibility and … from management at JGI and the other participating facilities, is then forwarded to DOE for final approval.  …

… by generating data in three overarching categories: DNA Sequencing , DNA Synthesis and Metabolomics .  Many users …

… your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … JGI and this was before they were integrated. So I thought, why not feed it in there. And I went to group meeting and … a particular signal with a particular synthase amino acid sequence we think that can be a great resource for the …

… environmental sustainability, and bioproducts. By sequencing and analyzing the genomes of these organisms, the … The Fungal & Algal Program harnesses cutting-edge sequencing technologies and advanced genomic analysis to … and biogeochemistry. The program’s focus is on large-scale sequencing efforts that survey the vast phylogenetic and …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore … The Microbial Program focuses on using advanced sequencing technologies to explore microbial diversity — … datasets, particularly for uncultivated microorganisms, by sequencing large populations of bacteria and archaea in …

… DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … communicate – lots of terpenes, and little modified amino acids, and things that they secrete out into the root … is similar to primary metabolism. So if you were, you know, sequencing an organism for the first time, and you’ve never …

… it so easily with fungi. So…   NANCY: Yeah, I don’t know why. For example, with that – actually there’s a good talk … everything is funding, right, isn’t it? I thank JGI for sequencing a lot of fungi. But the thing with them – to get … Joint Genome Institute, a DOE Office of Science User Facility located at Lawrence Berkeley National Lab. You can …

… biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … gene clusters. And I had heard the first rumors of people sequencing like these enormous numbers of genomes, like 20 … this, especially Christmas time when NAR, the Nucleic Acids Research that’s a journal that– Dan Udwary: Yeah. …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an ongoing … when you go way back, you think about the history, the capacity for diving only evolved in World War II with the …

… For accepted proposals, sequencing, synthesis, metabolomics and analysis will be … integrate the expertise and capabilities of multiple user facilities Investigators with DOE mission-relevant projects that call for expansive sequencing, synthetic biology, and metabolomics capabilities …