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… DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of the things I did want to … is similar to primary metabolism. So if you were, you know, sequencing an organism for the first time, and you’ve never … more knowledge you can generate. So that’s why we are still sequencing lots of stuff, and why the JGI is a key driver in …

… biological perspective, like what was this bacterium, and why did your group want to study it? Marnix Medema: You mean … gene clusters. And I had heard the first rumors of people sequencing like these enormous numbers of genomes, like 20 … Medema: Yeah. So that’s an ERC grant that we recently got awarded. And this is indeed one of the new directions that my …

… environmental sustainability, and bioproducts. By sequencing and analyzing the genomes of these organisms, the … The Fungal & Algal Program harnesses cutting-edge sequencing technologies and advanced genomic analysis to … and biogeochemistry. The program’s focus is on large-scale sequencing efforts that survey the vast phylogenetic and …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … about his move to microbiology, about drug discovery and why it’s so hard to succeed, and we talk about an ongoing … all excited about this project too. I’m really looking forward to seeing the data when it finally gets off the …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore … The Microbial Program focuses on using advanced sequencing technologies to explore microbial diversity — … datasets, particularly for uncultivated microorganisms, by sequencing large populations of bacteria and archaea in …

… which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … aiming for the first Thursday of the month moving forward. So, that’s the schedule, I’m committing to it, and you … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, …

… Overview The JGI provides sequencing, synthesis, and targeted metabolomics support for DOE-BER funded awards, including awards funded through  BER Funding … a core facility instead. Proposals may not exceed 10 Tbp sequencing, 500 kbp synthesis, and 200 polar/500 nonpolar …

… in natural products right. There’s many different avenues toward chemistry. But that’s kind of where I had you. How … does some really exciting work there. And I thought, well, why don’t we try to go to Alaska and see what we can find … really exciting work on figuring out how to get genomic sequencing data for the fungus garden because it’s more …

… and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – sequences … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … has the opportunity to, you know, use that research towards secondary metabolism aims. And we need new people – we …

… For accepted proposals, sequencing, synthesis, metabolomics and analysis will be … with DOE mission-relevant projects that call for expansive sequencing, synthetic biology, and metabolomics capabilities … Letters of Intent. Proposals may include synthetic biology, sequencing, and metabolomics. Proposals may include …

… The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … technology.] BETSY PARKINSON: OK. DNA affinity purification sequencing. And so the way this essentially works is you … PARKINSON: Yeah. We definitely follow up with them afterwards. And so we don't always have the ability to find the …

… your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … I think what a lot of people would consider more straightforward chemical biology, a lot of which people classify as … JGI and this was before they were integrated. So I thought, why not feed it in there. And I went to group meeting and …