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…   The JGI’s Secondary Metabolites Program focuses on the exploration of … metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential for fundamental growth, provide critical advantages to the … resources by exploring the genetic pathways responsible for their synthesis. The Secondary Metabolites Program …

… Our research is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics … insights into viral evolution and complexity, and encode for a treasure trove full of novel genes ready to be tapped …

… The Facilities Integrating Collaborations for User Science (FICUS) call … provides customized analysis, the JGI also participates in publication of results. … Proposals for the annual FICUS call with EMSL begin with a Letter … an LOI is accepted, the researcher then submits a proposal for consideration in the next review cycle. Initiate a full …

… and SIO. Oh, I should say what those are. Brad: What’s SIO, for all those listeners out there? Dan: Scripps Institution … before we’re even thinking of genes and connecting genes to molecules, which is something that, you know, we take for … so we’ve done some work to try to do some elicitation of production and did some meta-T [meta-transcriptomics] on …

… genome miners use, including antiSMASH, MIBiG, and newer efforts, like BiG-scape and BiG-SLiCE, and now the BiG-FAM … clusters across different species, which all encode the production of either the same or similar molecules. And then of course, where you draw the boundary …

… I think it must’ve been about 2001, maybe, and so it was before smartphones and before laptops and everything. And I … on ionizing, so you’re essentially getting only a subset of molecules that will fly on an analytical instrument and be … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… the series of interviews we recorded at the Society for Industrial Microbiology and Biotechnology (SIMB) Natural … work as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my … as a simple organic chemist, can I make that big, beautiful molecule? And so I’d like to think I’ve evolved a bit since …

… it’s a little hard to find in print, but we live in the information age and the ebook version is available at most … you need to go back to your extract and try to purify the molecule that’s causing that test to be successful. Right? … gene that’s likely to be involved in secondary metabolism – production, say of a certain molecule. If you can find one …

… Every approved proposal starts with a User Agreement — before any … rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is … of the JGI User Agreement , JGI User Agreement for Federal Agencies , DNA Synthesis Appendix  and DNA …

… DAN UDWARY: Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of … natural products, getting into the ocean and looking for molecules from the very beginning of the field. I learned a … that could afford to do all of the complex biology and production that we couldn’t do. So 2021, we have two drugs …

… The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with genomic … biogeochemical processes, development of high performance plants and microbes, and understanding microbiome … and the bioeconomy including understanding enzymatic transformations, pathways, and how changes in metabolism can …

… authentication enabled to log in. Check our Help Site for additional information, including a Login Walkthrough … project at any time by logging on to the My Data Portal using your JGI login . After sequencing/metabolomics has … access your data, share with collaborators, and coordinate publication with JGI scientists. Synthetic DNA constructs …