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… and SIO. Oh, I should say what those are. Brad: What’s SIO, for all those listeners out there? Dan: Scripps Institution … before we’re even thinking of genes and connecting genes to molecules, which is something that, you know, we take for … so we’ve done some work to try to do some elicitation of production and did some meta-T [meta-transcriptomics] on …

… genome miners use, including antiSMASH, MIBiG, and newer efforts, like BiG-scape and BiG-SLiCE, and now the BiG-FAM … clusters across different species, which all encode the production of either the same or similar molecules. And then of course, where you draw the boundary …

I think it must’ve been about 2001, maybe, and so it was before smartphones and before laptops and everything. And I … on ionizing, so you’re essentially getting only a subset of molecules that will fly on an analytical instrument and be … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… the series of interviews we recorded at the Society for Industrial Microbiology and Biotechnology (SIMB) Natural … work as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my … as a simple organic chemist, can I make that big, beautiful molecule? And so I’d like to think I’ve evolved a bit since …

Every approved proposal starts with a User Agreement — before any … rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

… work and outline roles and responsibilities resulting in a formal Statement of Work (SOW). All work performed at the … project at any time by logging on to the Genome Portals using your JGI login. After sequencing/metabolomics has … access your data, share with collaborators, and coordinate publication with JGI scientists. Synthetic DNA constructs …

… it’s a little hard to find in print, but we live in the information age and the ebook version is available at most … you need to go back to your extract and try to purify the molecule that’s causing that test to be successful. Right? … gene that’s likely to be involved in secondary metabolism – production, say of a certain molecule. If you can find one …

The JGI’s Microbial Program focuses on using cutting-edge sequencing, … inter-organismal interactions. These insights are crucial for addressing key environmental challenges, such as …

… -omics technologies at the JGI by identifying the actual molecules present in an environment that influence system … of new molecules and pathways. The JGI Metabolomics Platform delivers rich metabolite profiles from diverse biological and environmental samples using advanced liquid chromatography mass spectrometry …

Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with genomic … biogeochemical processes, development of high performance plants and microbes, and understanding microbiome … in your custom Python applications but highly recommend using the workflow in  GNPS2 .   … In support of user …

… … DAN UDWARY: Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of … natural products, getting into the ocean and looking for molecules from the very beginning of the field. I learned a … that could afford to do all of the complex biology and production that we couldn’t do. So 2021, we have two drugs …

… to environmental changes. The program lays the groundwork for sustainable solutions to current problems facing … agriculture, including the development of complex biomolecules — which can include antimicrobial and anti-pest … the ability to discover syntenic orthologs, generate publication quality graphics and explore pangenome views of …