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They all have very developed secondary metabolism pathways. Not every organism, at least, has something that’s … so secondary metabolism is throughout nature, except maybe for animals and humans, not as much. You know, we have this … metabolism, has been … not dominated by, but driven by drug discovery. We know that many natural product molecules are …

Overview The JGI provides sequencing, synthesis, and targeted metabolomics support for DOE-BER funded awards, including awards funded through  … ,  Science Focus Areas  (SFA) opportunities, and the  Office of Science Early Career Research Program .   If …

… the modern, post-golden age history of natural products discovery, and we’ll talk a lot about the current state of … you’re going to find another 20 or 30 secondary metabolism pathways that you didn’t even know existed. And so, that … not actually on the structure of the protein that you’re engineering… Yeah, the complete system. So there’s more to …

Our research is focused on the discovery and characterization of novel bacterial, archaeal … and biogeochemical cycles. Research Team    … A complete publication list available at Google Scholar. Schulz, C … The ISME Journal. 8 (8), 1634-1644 … Publications … For further details, please reach out to the Group Lead …

… uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … diversity and metabolic potential, with implications for energy production, environmental sustainability, and … that support user analysis of biogeochemically-relevant pathways, enabling modeling of microbiomes based on …

… … DAN: Welcome back for episode 9 of Natural Prodcast. This week, Alison and I talk to Roger … Bill Gerwick as part of the International Biodiversity Drug Discovery consortium doing natural products …

… of secondary metabolism.  DAN: Hello, and welcome back for Episode 7 of the Natural Prodcast. It’s been about a … that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, great. Are any of these antibody-drug … CRISPR technology, anything as genome editing, genome engineering, to make something even better and making more …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … Takemura, whose voice you’ll hear in a minute – we work for the US Department of Energy Joint Genome Institute, or … ALISON: Okay. We’re looking at a schematic of different pathways in a microbial cell, it looks like. It could be a …

… enjoyed what he was doing so I wanted to be part of that discovery, and that magic that he was showing, and in his … , but circular. 10% of the genome encoded natural product pathways. Dan: Yeah, that’s kind of a trend now. But at the … medicine” as a way of the future. We’re really good at engineering small molecules into microbes and making those …

… identify and interpret biosynthetic, secondary metabolism pathways. And today, we get to present our conversation with … However – and this was a proposal on synthetic biology of engineering gene expression in bacteria – however, the … relates to a whole different field like computational drug discovery field, which has been quite distinct from the …

The Facilities Integrating Collaborations for User Science (FICUS) call represents a unique … for researchers to request the capabilities and expertise of multiple DOE National User Facilities in one research … provides customized analysis, the JGI also participates in publication of results. … Proposals for the annual FICUS …

Data produced and released by the US Department of Energy (DOE) Joint Genome Institute (JGI) are subject to … Data Policy. It is our mission to support open data and information sharing. We also recognize the need to have a … PIs or co-PIs) who wish to include use-restricted data in publications, or who wish to redistribute data in any way …