Search

… joined the JGI in 2017, he brought with him 20 years of industry experience — and an opportunity to expand the … in 2025, the initiative aims to accelerate scientific discovery, strengthen national security and ensure U.S. … and curated data to support AI applications. In an effort to lead AI-driven genomic innovation to advance …

… of secondary metabolism.  DAN: Hey there and welcome back for Episode 8 of Natural Prodcast. This week, we have our … it, but it has a really fun and interesting biosynthetic pathway, and I’ll have to do a whole show on it one of these … in that. And we have a project working on pain drug discovery from those animals. A second area that I’m really …

… Every approved proposal starts with a User Agreement — before any work can begin, including the submission of samples for sequencing, or the submission of sequencing … rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

… the modern, post-golden age history of natural products discovery, and we’ll talk a lot about the current state of … you’re going to find another 20 or 30 secondary metabolism pathways that you didn’t even know existed. And so, that … not actually on the structure of the protein that you’re engineering… Yeah, the complete system. So there’s more to …

… They all have very developed secondary metabolism pathways. Not every organism, at least, has something that’s … so secondary metabolism is throughout nature, except maybe for animals and humans, not as much. You know, we have this … metabolism, has been … not dominated by, but driven by drug discovery. We know that many natural product molecules are …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, … analysis techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … inter-organismal interactions. These insights are crucial for addressing key environmental challenges, such as …

… DAN: Welcome back for episode 9 of Natural Prodcast. This week, Alison and I talk to Roger … Bill Gerwick as part of the International Biodiversity Drug Discovery consortium doing natural products … Episode Transcript … chemist, and his research group works in metabolomics, drug discovery and screening, structure elucidation, and chemical …

… The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … diversity and metabolic potential, with implications for energy production, environmental sustainability, and … that support user analysis of biogeochemically-relevant pathways, enabling modeling of microbiomes based on …

… of secondary metabolism.  DAN: Hello, and welcome back for Episode 7 of the Natural Prodcast. It’s been about a … that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, great. Are any of these antibody-drug … CRISPR technology, anything as genome editing, genome engineering, to make something even better and making more …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … Takemura, whose voice you’ll hear in a minute – we work for the US Department of Energy Joint Genome Institute, or … ALISON: Okay. We’re looking at a schematic of different pathways in a microbial cell, it looks like. It could be a …

… enjoyed what he was doing so I wanted to be part of that discovery, and that magic that he was showing, and in his … , but circular. 10% of the genome encoded natural product pathways. Dan: Yeah, that’s kind of a trend now. But at the … medicine” as a way of the future. We’re really good at engineering small molecules into microbes and making those …

… identify and interpret biosynthetic, secondary metabolism pathways. And today, we get to present our conversation with … However – and this was a proposal on synthetic biology of engineering gene expression in bacteria – however, the … relates to a whole different field like computational drug discovery field, which has been quite distinct from the …