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… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something … to being deployed.” But we didn’t get to talk about any specific project. So this is really exciting. Brad: Yeah! …

… The JGI’s DNA Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … The DNA Synthesis Program plays a central role in advancing functional genomics, focusing on developing genetic systems that can address global energy and …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … spent your whole career as far as I’m aware working on specifically fungal natural products and fungal …

… the most effective application, of marine molecules in general. DAN UDWARY: Maybe can you explain to our audience … in chemotherapy. Because 99.9% of cancer drugs are not so selective that they don’t have an impact on normal cells, … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … and actually get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary … systems are also everywhere – that there are some very specific patterns and shared DNA across all of these things. …

… Natural Prodcast is a “fireside chat”-style podcast about … species unique and different from one another. They are incredibly important to medicine, the environment, and human health. As the JGI acts on …

… was really before– or kind of around about when the first genome sequencing was done. But natural products– marine … I was imagining some massive contraption for amplifying genes. I wasn’t really sure what actinobacteria were. Dan … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such … that are from candidate phyla, major branches in the phylogenetic tree without cultivated representatives. The “Great …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … that produces those. So it’s not a hard and fast rule, but, generally, animals do not have secondary metabolism that we … the drug. So for example, a lot of antibiotics will target specific parts of a cell wall. And so if you weaken a cell …

… Menaka Wilhelm, who is the host of JGI’s other podcast, Genome Insider . If you’re a Genome Insider listener, then … I think for Natural Prodcast, I think the question that generally comes up that people come to me asking like is– … do the bioinformatics and to synthesize these results into publication? So there’s this really important because we …

… enzymes to do chemical reactions. Obviously, in my work, in genome mining, we have an awful lot of crossover, where us … comes to biocatalysis? You want your reactions to be very selective in terms of the products that they’re making. And … could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: …