Search

… biosynthetic gene clusters in your organism that you love dearly and can genetically manipulate. And yeah. And so … And it’s surprising even though the first signal was characterized I think in the ’70s. It’s still almost … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

… for researchers to request the capabilities and expertise of multiple DOE National User Facilities in one research … provides customized analysis, the JGI also participates in publication of results. … Proposals for the annual FICUS … of the participating User Facilities, as well as DOE. Nearly all LOIs are accepted for full proposal submission, …

Biology is currently experiencing a revolution brought on by rapid developments in genomics and … LB et al. (2017) A thermostable Cas9 with increased lifetime in human plasma.  Nat Commun . 8(1):1424. Sczyrba … Science 344(6186):909-13 … Research Efforts … Selected Publications … For further details, please reach out to the …

Dan, when you were supposed to visit us in the Netherlands early this summer, then it was– well, I think the day your … in more detail. Especially if you want to look at the evolution of these gene clusters, for example, you really … your own computer. MIBiG is a repository of experimentally characterized and manually annotated BGCs. And now BiG-SCAPE …

… part of the first one that you were on. But that’s not nearly enough. And so I thought it would be good to spend … really not like anything that’s been identified to date and characterized to date. So we’re one, looking at how unique … And I think a lot of times, too, when we even look at publications, it’s always positive data, right? No one ever …

… analysis techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … Novel approaches are being explored to predict microbial lifestyles using AI-driven analysis of such datasets. The … families, and pathways, enhancing our understanding of evolutionary diversification and microbial diversity. Learn …

… and maths– but there’s actually more women than men in life sciences at the undergraduate level. However, at the … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to … data of– if you look at molecular networks and how much is characterized and how much is unknown, we need to start …

… cells. So, the very first compound was introduced in the early 90s and by using a polymer as a delivery mechanism. … for which, by genome sequencing, we know they are more proliferative than the enediyne we have isolated to date by the … among many, many major discoveries since the genomic revolution, to me, as a natural part chemist for microbial …

… because we can find more things. Turns out some of the early genomes that were sequenced for, say, Streptomyces – … and another system. There should be. I mean, there’s some evolution that happened. But, you know, bacteria don’t leave … of these biosynthetic clusters that we’re interested in, characterize what those molecules actually are, and then …

… got this very sugary environment. It’s a compound that clearly kills things that would otherwise consume substrates … some sigma factor work and anti-sigma factors. in my past life.  DAN: Yeah, I didn’t really appreciate that that’s … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

Brian went on to work at a groundbreaking company in the early 2000s called Ecopia, which was a very early genome … And I said, well, it’s possible to do this. And life has figured out how to do this. So I started to look … school, then Frances Arnold’s papers came out, directed evolution, and Pim Stemmer. And at the time, I thought that …

… spec seeing different levels go up and down. We're pretty early on in that project. I will fully admit that, but it's … and other-- DAN: True. BETSY PARKINSON: --aspects of the life cycle, but we're just particularly interested in their … doing so far, we've primarily been working with previously characterized gamma-butyrolactone receptors, and now we …