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… in chemical enzymology. So, we talked about her JGI DNA synthesis project to explore the chemical capabilities of … independent monooxygenases with the help of JGI’s DNA synthesis grant. And that having a whole panel of these … I think back to when I was a graduate student doing total synthesis where our gold standard was, if you’re doing three …

… genomes provide new insights into an ancient metabolism. Methane is a greenhouse gas 20 times more potent than carbon … and the presence of methanogens in nearly all types of anaerobic environments suggest the diversity of methane … “Distribution of predominant high-temperature archaeal and bacterial lineages in Yellowstone National Park,” as well as …

… laboratory isolation and genome sequencing of underexplored bacterial and archaeal lineages that are important for … space:  The JGI generates reference genomes from diverse bacterial and archaeal lineages to improve phylogenetic …

… committees, such as the User Executive Committee, the DNA Synthesis Science User Advisory Committee, the Fungal and …

… Cycle Time FY25 Q1  (median/75th percentile*) DNA Synthesis Constructs <5kb in size Single gene or multiple … choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs 5-10kb in size Single gene or multiple … choice Glycerol stock of sequence verified clone 170/NA DNA Synthesis Constructs >10kb in size Gene clusters or pathways …

… Metagenome, Metabolomics, Secondary Metabolites, and DNA Synthesis Science Programs and draw from the infrastructure …

… are reviewed annually. For accepted proposals, sequencing, synthesis, metabolomics and analysis will be provided for …

… state-of-the-art sequencers and platforms dedicated to synthesis, single-cell analyses and metabolomics. At the …

… by exploring the genetic pathways responsible for their synthesis. The Secondary Metabolites Program offers users … and refining experimental approaches to explore the synthesis and function of these biologically significant … for substrates to be directed towards secondary metabolite synthesis. We are currently exploring  Escherichia coli and  …

… and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … gene clusters, which are the genes that do the biosynthesis of a secondary metabolite, those are clustered … of Earth’s Microbiomes. And what this is, is a data set of bacterial and archaeal genomes that were created – these are …

… organs that solely house– whose sole function is to house bacterial associates. And so the one that the Hawaiian … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … in the organism in its sequence that encode for that biosynthesis. But sometimes you have to know what those are in …