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… I was like, no, I’m going to study architecture. I like making things and designing things. I’m going into … out with a parent who then doesn’t become your parent anymore, but has this other role in your life. A colleague, ya … that, right? I think that was the first perhaps the only case of a genome assembly being aided by a chemical entity. …

… of secondary metabolism.  DAN: Hello, and welcome back for Episode 7 of the Natural Prodcast. It’s been about a … six episodes, and now after gathering some feedback and making a few technical tweaks, I think we’ll be on a pretty … – the enediyne compound that people know, as a family, it’s more than 7 decades. So, this family of substances is always …

… or through the JGI website at jgi.doe.gov . There’s a lot more to talk about there, and I’ll be getting together a … it can be looking for drugs from marine organisms, in which case you get to go to exotic tropical locations and go … But I couldn’t stop thinking, well, these organisms are making these compounds. It looks a lot easier than what I’m …

… “Adopt a Genome” is an informal program for faculty to “claim” the JGI’s unpublished microbial genomes, with the expectation that faculty will work with … insights from sequence data, employing IMG data and tools for comparative analysis, visualization and interpretation …

… staff in the Integrative Genomics Building in Berkeley, California.  Our location at the IGB fosters team science and … biotechnology through analyzing and harnessing genomic information from plants, fungi, algae, non-medical microbes, … of four partner institutions: Berkeley Lab, Lawrence Livermore National Laboratory , the HudsonAlpha Institute for …

… project, which you’ll hear him describe. [ Go here to learn more about Tiny Earth and the JGI’s role in the project by … bit of my newer work is focused on plants, but in both cases, you know, these molecules are how microbes … research-as-learning course. So they’re in the lab, they’re making discoveries, there is no like, you know, do your …

… Takemura, whose voice you’ll hear in a minute – we work for the US Department of Energy Joint Genome Institute, or … even though the science in that Facebook post is probably more than a little fuzzy. The natural products – or … you can smell it. That fresh dirt smell: that is bacteria making natural products  ALISON: Hmm. It kind of – it’s kind …

… coming out of that conference, and there should be a few more in the feed, that I’m releasing along with this one, at … with the bacteria that you’re working with. Is that the case for fungi?   NANCY: I think a lot of labs yet are doing … if you looked at the statins, you might find many fungi are making similar looking statins. But, this one could be …

… specializations and the things that we dig into maybe a bit more than others. Kate Duncan: Yep. Dan Udwary: You know, … or antibiotics and stuff like that. Dan Udwary: Yeah, making biofuels has to be really cost-efficient or you have … One, growing the micro-organism– actinobacteria in this case– in the lab, you are only going to– you’re giving it …

… this description, but I’d say that Alison is not one of the more normal kinds of natural products people we usually talk … of the structures and also the challenge and thinking about making them. So I really came at it not necessarily based on … heard that before. Why is that? Why would that be the case? ALISON NARAYAN: It’s a great question. If you dive …

… on as an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … most decorated and legendary natural products people– he’s making a face. Talking to us today is Bill Fenical from … that should be is a microbiological puzzle, but it’s the case. This was one of the first ones that we worked on, …

… cool stuff with cool bacteria that I’m fascinated to learn more about. He works with methylotrophs, which are a group … the anaerobic ecosystem. And you have some oxygen that is making its way down. And in that Goldilocks zone is where … these quorum sensing systems which again would just in many cases be these two genes for a synthase and a transcription …