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… we are today, recording today. BRIAN BACHMANN: Yeah, in the year 2000. And I was trying to figure out what to do with … how much blood, sweat, and tears went into trying to identify that you had the right cluster before you sent it out for … And I set that up. And we finally got that to work 10 years later. But in the meantime there, we had people …

… chemical biology, a lot of which people classify as tool building. So I worked with a really great guy … AARON PURI: Sure. Great. I have a job for a couple of years. But the other thing that we can do that we’ve been … by Inverse Stable Isotopic Labeling . ACS Chem Biol. 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

Program leads to discuss available options. Note: In 2021, we conducted an extensive internal product audit to … Program Product Description Deliverables Cycle Time FY25 Q1  (median/75th percentile*) DNA Synthesis Constructs … vector of choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs 5-10kb in size Single gene …

… advisor.  Brad: Oh my goodness. Those were good years, Dan!  Dan: For too many years. Brad: And now look, … pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … cool because the work has gone so much more than just identifying genes to that toxin, but it’s opened up this whole …

… has a book called The Plant Hunter and I’ve read all 400 pages of her life and I feel like I have a new friend that … And so a path opened itself to me, just before my senior year of college, a chance to go to the Amazon and work with … they were starting to show the ability to really identify, and get crystal structures out of these mixed powders, …

Biotechnology (SIMB) Natural Products meeting earlier this year. And today we have our conversation with Professor … I always use it as the first word in the title of my talk, 100% fair for you to make that association. DAN UDWARY: So I … the oxidized form, and so you see your proteins– very gratifying, when you do a protein purification out of this, like, …

So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we … as a new type of medicine that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, … if you are a microbiologist in the 40s, how do you classify a strain? You look at it and this is the 40s – you don’t …

… houses Vibrio fischeri, it’s one strain and there have been years and years and years about 35-ish years, I think, now, … so there are– I hesitate to make a guess but maybe 50 to 100 different strains and they are in individual tubules.  … if they’re not clustered then maybe we’re not really identifying them very well. For sure. But plants certainly make …

… of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary metabolism … that, I wanted to tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve got the t-shirt on …

During the summer of 2021, 13 interns from UC Merced spent eight weeks working … development enrichment activities. For some students in the 2021 cohort, this was their first internship experience, … returned to re-engage with their mentors from the previous year and continue working on their research project! The …

… then you need to go back to your extract and try to purify the molecule that’s causing that test to be successful. … natural product molecules might actually get to market in a year. And that would be a good thing. That would be high. … the number was. But I want to say it was like less than 10. Since, you know, a recent decade.  DAN: I’m sure that’s …

Congratulations to the 2021 Highly Cited Researchers at the JGI! They are among … rank in the top 1% by citations for field and publication year are: Igor Grigoriev Natalia Ivanova Nikos Kyrpides Dan … researchers were involved in, reported on over the last year: Jeremy Schmutz was part of a long-term …