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… as a new type of medicine that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, … genome, the genome predicts they often can produce around 30 – more than 30 compounds. So, this was a complete … if you are a microbiologist in the 40s, how do you classify a strain? You look at it and this is the 40s – you don’t …

… advisor.  Brad: Oh my goodness. Those were good years, Dan!  Dan: For too many years. Brad: And now look, … cool because the work has gone so much more than just identifying genes to that toxin, but it’s opened up this whole … with us? Brad:  Unfortunately, not. We lost him about 13 years ago. So, I wish he was still with us because I know …

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… we are today, recording today. BRIAN BACHMANN: Yeah, in the year 2000. And I was trying to figure out what to do with … they had the same conserved polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: … how much blood, sweat, and tears went into trying to identify that you had the right cluster before you sent it out for …

… was at the Broad Institute in Cambridge, Mass. for a couple years before joining Warp Drive. And what kind of pushed me … to be involved in signaling. We’re not perfect at identifying what these pathways are yet. So there’s still a lot to … have no extra genes hanging around, they still dedicate 20-30% of their genome to secondary metabolism. So it’s very …

… there. This is Dan again, and you’re about to listen to the 3rd and final part of Natural Prodcast’s “Primer” episodes. … then you need to go back to your extract and try to purify the molecule that’s causing that test to be successful. … natural product molecules might actually get to market in a year. And that would be a good thing. That would be high. …

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… of genome mining, which is using DNA sequence to identify and interpret biosynthetic, secondary metabolism … that, I wanted to tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve … that I was exchanging with people. So I think I wrote 3,000 emails in the course of one and a half year while …

I mean, I am– yeah. I just got the position like three years, four years– four years ago I think. Yeah. Yeah, Paul … all these 120 genomes, and each of them have– I don’t know– 30 gene clusters or so. So I think I spent two years only … tools for natural product researchers that easily can identify secondary metabolite pathways in metagenomes, which is …

… available from all the facilities participating in the FY25 call, introduces the resources available from the … useful tips for submitting a successful proposal. … The FY23 FICUS Open Call for Proposals describes the resources …

… outcome of the innovative research  being proposed by this year’s CSP investigators,” said Tanja Woyke, Deputy Director …