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… metabolism and centralized metabolism, or what a secondary metabolite is versus what a specialized metabolite is, then … work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can … information. It could be a very unstable interaction, mediated by this antibiotic. So you can start looking into …

… to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those associated with … to explore microbial diversity — with an emphasis on bacteria and archaea, and including those associated with … microorganisms, by sequencing large populations of bacteria and archaea in their natural environments using …

… cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … This is a dynamic and complex ecosystem that includes bacteria, fungi, viruses. Resident viruses can be found in a myriad of bacterial strains, whereby they can modulate host …

… of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … … show that the gap between cultivated and uncultivated Bacteria and Archaea has steadily been widening since 2005. … T ., Klenk H. P., Kyrpides N. C. 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree …

… find, things that are of interest. And usually, in terms of bacteria and secondary metabolism, those things that we want … se, how do you see genome mining and looking for secondary metabolites in the genome as relevant to the JGI mission? … because a lot of secondary metabolism is horizontally transferred. Things shift between even different genus. And …

Genomics group . Research Team … Coclet, C. and Roux, S. (2021) Global overview and major challenges of host … Opinion in Virology .  49 , 117-126 Berg, M. and Roux, S. (2021) Extreme dimensions — how big (or small) can tailed … viral infection cycle in wild populations of green sulfur bacteria with long standing virus-host interactions. ISME J. …

… on synthetic biology of engineering gene expression in bacteria – however, the professor was actually quite … gene clusters. And also correlating these gene clusters to metabolites. So knowing, OK, which metabolites are actually associated with these gene …

… colleagues. Aaron is doing some cool stuff with cool bacteria that I’m fascinated to learn more about. He works … as we were mentioning before, of more complex secondary metabolites that an organism might want to use to affect its … by Inverse Stable Isotopic Labeling . ACS Chem Biol. 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

… about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of natural product biosynthetic … pathways, which led her to a successfully funded JGI CSP project. And we also got to talk about work at her …

… behave in certain solvents or certain reactions or mixtures temperature, do you do take that into account? Or do you and … proteins, I mean, what– from your perspective, like, what temperature would you want to push them to be able to still … organisms where their peak activity is at an elevated temperature. Right? We don’t necessarily see that the …

… chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your crazy Aunt … Nigel Mouncey, started and leads the JGI’s Secondary Metabolites Science Program, which I was hired into, and my … probably some historical evolutionary event where the DNA transferred from the fungus into the tree and became …

… been dominated for … well, as long as I can remember, by bacterial research.  So it was great to hear her passion and … on aflatoxin biosynthesis, aflatoxin being a secondary metabolite from an Aspergillus species that is pretty toxic … this one could be really good because, hey, it had a methyltransferase that changed. And, you know, I wish we could …