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… And a lot of us moved on to work in simpler systems, like bacteria, where we figure we can make more progress faster, … are built up from amino acids, so they’re secondary metabolite peptides. And there are two ways that nature does … we’ve worked both with the microbiome. So, with symbiotic bacteria that live in animals and with animal metabolism …

… metabolism and centralized metabolism, or what a secondary metabolite is versus what a specialized metabolite is, then … work like ActDES, which is a curated database of actinobacteria for evolutionary studies, and hopefully we can … information. It could be a very unstable interaction, mediated by this antibiotic. So you can start looking into …

… to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those associated with … to explore microbial diversity — with an emphasis on bacteria and archaea, and including those associated with … microorganisms, by sequencing large populations of bacteria and archaea in their natural environments using …

… find, things that are of interest. And usually, in terms of bacteria and secondary metabolism, those things that we want … se, how do you see genome mining and looking for secondary metabolites in the genome as relevant to the JGI mission? … because a lot of secondary metabolism is horizontally transferred. Things shift between even different genus. And …

… of microbial metabolism towards a minority of cultivated bacteria, still persists to date. Research Team    … show that the gap between cultivated and uncultivated Bacteria and Archaea has steadily been widening since 2005. … T ., Klenk H. P., Kyrpides N. C. 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree …

… cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … This is a dynamic and complex ecosystem that includes bacteria, fungi, viruses. Resident viruses can be found in a myriad of bacterial strains, whereby they can modulate host …

… on synthetic biology of engineering gene expression in bacteria – however, the professor was actually quite … gene clusters. And also correlating these gene clusters to metabolites. So knowing, OK, which metabolites are actually associated with these gene … a fantastic set of software tools for exploring secondary metabolite biosynthetic gene clusters (BGCs). Most people in …

… requesting DNA synthesis from JGI, there's also a material transfer agreement that’s required. Please refer to the … organisms and mixed cultures of fungi, algae, protists, bacteria, archaea, viruses, plants, including microbial … growing anaerobes and phototrophs. Note that utilization or transfer of any genetic resource may be covered by local, …

… colleagues. Aaron is doing some cool stuff with cool bacteria that I’m fascinated to learn more about. He works … with methylotrophs, which are a group of carbon-fixing bacteria that I would say are are still fairly unexplored in … as we were mentioning before, of more complex secondary metabolites that an organism might want to use to affect its …

… about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of natural product biosynthetic … pathways, which led her to a successfully funded JGI CSP project. And we also got to talk about work at her … with Elizabeth "Betsy" Parkinson, from Purdue, about bacterial signaling molecules and regulation of biosynthetic …

… Our lab is using mass spectrometry based metabolite profiling to provide direct biochemical datasets … interest is understanding the distributed and dynamic metabolite networks of environmental microbes and how they …

… chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your crazy Aunt … Nigel Mouncey, started and leads the JGI’s Secondary Metabolites Science Program, which I was hired into, and my … probably some historical evolutionary event where the DNA transferred from the fungus into the tree and became …