Search

… felt kind of like training for a marathon by running at a high altitude! And a lot of us moved on to work in simpler … way of making proteins, with a ribosome. Then, some other enzymes chop the protein into smaller pieces, and other … in that. And we have a project working on pain drug discovery from those animals. A second area that I’m really …

… as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my work, in … And you want to have good binding to your substrate and high turnovers. But if you have those things, can you also … are natural sequences, and we chose several of them to be highly related to enzymes that we have been studying since …

… first described by Stanley and Konopa in 1985, which highlights our skewed understanding of microbial metabolism … the metabolic potential of uncultivated lineages is of high value to establish models and hypotheses, experimental … S.G., Visel A., Woyke T ., Wang Z. & Rubin E.M. Metagenomic discovery of biomass-degrading genes and genomes from cow …

… cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … viruses. Resident viruses can be found in a myriad of bacterial strains, whereby they can modulate host … function of these phage genes is the modulation of their bacterial host to colonize plant roots, as with Arabidopsis …

… mining and the directions it might take in the future. I highly recommend it. I’ll link to it in the show notes. … we can use that knowledge to actually use it in drug discovery, right? I mean, at the end, we somehow have the … is not on the data side, but it’s still really the high throughput of getting these clusters activated. So most of …

… Computing Center ( NERSC ) is to accelerate scientific discovery at the DOE Office of Science through high performance computing (HPC) and data analysis.  The DOE … To jointly support these missions, and to expand upon highly successful past collaborations, the DOE JGI, NERSC …

… The CSP and FICUS calls are open to both domestic and … Agreement must be signed before work can begin, and all CSP proposals are subject to JGI policies on Data Release and Publication .   Except for applicants to the CSP New Investigator call, investigators may have existing …

… R. Seshadri, M. Escobar. Draft genome sequences of two bacterial type strains isolated from a methanogenic … Draft genome sequences of three ruminant-associated Eubacteriales: Eubacterium ruminantium ATCC 17233T, … R. Seshadri, and C. Stephens. Genome sequences of key bacterial symbionts of entomopathogenic nematodes: …

… and he’s doing some amazing research in and around drug discovery, which includes screening methods, genome mining … on many areas of natural products biosynthesis and drug discovery. If you enjoy the interview, I’d encourage you to … what led me to natural products. So after realizing that enzymes were specific for their substrates, that you …

… a science-y kid? JACLYN WINTER: I was not actually. So in high school, I didn’t– well, I guess– I mean, a few people I … in natural products, and especially if you’re in the drug discovery angle, is to look in industry. But you’re a … has been doing work in secondary metabolism. The very first CSP I ever worked on back in Brad’s lab, we talked about it …

… Bill Gerwick as part of the International Biodiversity Drug Discovery consortium doing natural products … and so the quality – the data quality – was reasonably high. And yeah, it gave it gave us enough enough pairs of … difficult before the advent of two dimensional NMR and high resolution mass spectrometry. And so some of those …

… Congratulations to the 2021 Highly Cited Researchers at the JGI! They are among those … a JGI Engagement Webinar on How to Successfully Apply for a CSP Proposal. She also co-organized the NeLLi 2021 …