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… bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … has been doing work in secondary metabolism. The very first CSP I ever worked on back in Brad’s lab, we talked about it … was the Salinispora genome project. And that was a JGI CSP project. They sequenced that genome for us at a time …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … efforts in paired-omics data sets and seeking to interpret function from BGCs. It’s a long, wide ranging conversation … Island. And was working on a natural products/biosynthetic gene cluster database, and a tool for predicting natural …

… It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a year, a full gene cluster would come out. And it was a very exciting … which is an octasaccharide and contains orthoester linkages and a couple of aryl groups. And it’s a complicated …

… critical requirements for amplifying the JGI’s impact. Data generated from a single investment will be reused for … integrated context. IMG/M provides tools for analyzing the functional capability of microbial communities based on … host taxonomy, conjugation potential, antibiotic resistance genes, and ecosystem information. …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … spheroides . And that got me really interested in microbial gene regulation and some pathways. And I thought I’d take an … it’s really about what are they doing. And so it’s really functional genomics. And there’s a lot of sequencing based …

… on large-scale sequencing efforts that survey the vast phylogenetic and ecological diversity of fungi and algae, examining both natural populations and engineered strains. This approach allows for the identification of key functional traits that have direct applications in bioenergy …

… sentence. I think that sometimes, we think about enzyme function is we think about the natural function versus can … could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: … to test that hypothesis through site-directed mutagenesis, we would end up with dead enzymes. So often, when …

… seems hard to believe in retrospect. BILL FENICAL: Well, in 2021, absolutely hard to believe. But when you go way back, … I think you’re right. I mean, that too was an issue. What function, what utility, what kind of applications might … the most effective application, of marine molecules in general. DAN UDWARY: Maybe can you explain to our audience …

… while nurturing a fresh cohort of users Reach the next generation of genome scientists and recruit new talent for …

… ] Each year, the JGI accepts proposals for state-of-the-art functional genomics research from scientists who translate … genomic information into biological function. Through our  CSP Functional Genomics call , we look for projects that … and omics capabilities to enhance understanding of gene and genome function. Tapping into these functions …

… the JGI’s focus on expanding molecular capabilities and functional genomics, scaling capacity through end-to-end … Functional Genomics Methods Click the drop-downs on the left …

…   Each year, the JGI accepts proposals for state-of-the-art functional genomics research from reseachers who translate … genomic information into biological function. Through our CSP Functional Genomics call , we look for projects that … and omics capabilities to enhance understanding of gene and genome function. Tapping into these functions …