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… genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something that, you know, we … JGI projects over the years starting with, you know, the CSP that we did and then leading up to today to some …

Yeah, so any metabolite, produced by bacterial or fungal metabolism by microbes, will have a functional role. … the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … a very unique on one compound. So cahuitamycin is an antifungal that will actually protect the fungal farms from …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … And Alison has done a really nice job of providing that general scientific audience whereas now I’m sitting here … of these or any organisms. So developing good heterologous expression hosts like maybe in many fields now like in …

… to the user and no granting of funds.   Proposal Call FICUS CSP Large Scale CSP New Investigator CSP Functional Genomics Status CLOSED CLOSED ONGOING ONGOING …

… in. All proposals must be written in English. … The CSP and FICUS calls are open to both domestic and … from any institution type and at any career stage. Generally, most users are able to work with Berkeley Lab.  … Agreement must be signed before work can begin, and all CSP proposals are subject to JGI policies on Data Release …

… conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … uncover these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The … pathway analysis, optimization of cell- and cell free-based expression platforms, tools and data for deciphering …

… on the largest analysis of 5mC distribution across the fungal tree of life to date, involving more than 500 species … one reference genome for every family of fungi, the 1000 Fungal Genomes initiative of the U.S. Department of Energy … that unlike most flowering plants and animals, fungi lack gene body methylation. The analysis revealed that 5mC in …

I was imagining some massive contraption for amplifying genes. I wasn’t really sure what actinobacteria were. Dan … to you, but they’re unprecedented in the terms biosynthetic gene clusters and genome size. And they’re so complex. … in Antarctica on a ship. Yeah, so I went to Antarctica in 2018 as a participant in Homeward Bound 2, last year as …

… industry engagement through three primary routes:  … The CSP provides the scientific community at large with access … right, title, and interest to any intellectual property generated under the agreement. … CRADAs enable research … and have the first right to license Lab inventions generated through the CRADA.  … New Leaf Symbiotics …

ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … it has a really interesting biosynthetic pathway because fungal genes are cool. And if you like fungal genes, you … and do the biochemistry to understand what the biosynthetic conversions were and what the mechanisms enzymatically were. …

The Community Science Program (CSP) provides the scientific community at large with access … of disciplines. Three calls fall under the umbrella of our CSP: The Large Scale call is for expansive projects that … the completion of a project, the JGI makes the assemblies, gene annotations, and analyses available to the community at …

Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … the program enables the design and synthesis of complex genetic pathways and biosystems. It The program fosters … fungi. Mycocosm enables users to navigate across sequenced fungal genomes, and to conduct comparative and …