Search

… episode is our conversation with Nancy Keller, a fantastic fungal natural products researcher from the University of … that you are the first person we’ve had on to talk about fungal natural products. I can say that I started in fungal … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was …

… Yeah, so any metabolite, produced by bacterial or fungal metabolism by microbes, will have a functional role. … the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … a very unique on one compound. So cahuitamycin is an antifungal that will actually protect the fungal farms from …

… The CSP and FICUS calls are open to both domestic and … from any institution type and at any career stage. Generally, most users are able to work with Berkeley Lab.  … Agreement must be signed before work can begin, and all CSP proposals are subject to JGI policies on Data Release …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … And Alison has done a really nice job of providing that general scientific audience whereas now I’m sitting here … of these or any organisms. So developing good heterologous expression hosts like maybe in many fields now like in …

… I was imagining some massive contraption for amplifying genes. I wasn’t really sure what actinobacteria were. Dan … to you, but they’re unprecedented in the terms biosynthetic gene clusters and genome size. And they’re so complex. … in Antarctica on a ship. Yeah, so I went to Antarctica in 2018 as a participant in Homeward Bound 2, last year as …

… the user and no granting of funds.    Proposal Call FICUS CSP Large Scale CSP New Investigator CSP Functional Genomics JGI-TMF Critical Minerals and …

… conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … uncover these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The … pathway analysis, optimization of cell- and cell free-based expression platforms, tools and data for deciphering …

… on the largest analysis of 5mC distribution across the fungal tree of life to date, involving more than 500 species … one reference genome for every family of fungi, the 1000 Fungal Genomes initiative of the U.S. Department of Energy … that unlike most flowering plants and animals, fungi lack gene body methylation. The analysis revealed that 5mC in …

… ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … it has a really interesting biosynthetic pathway because fungal genes are cool. And if you like fungal genes, you … and do the biochemistry to understand what the biosynthetic conversions were and what the mechanisms enzymatically were. …

… that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their … of many different things in microbiology and biology in general. And her efforts first at Yale and now at University … this and deal with it is through these antibiotic- or antifungal-producing bacteria that live on the exoskeleton of …

… Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … the program enables the design and synthesis of complex genetic pathways and biosystems. It The program fosters … in advancing functional genomics, focusing on developing genetic systems that can address global energy and …

… The Community Science Program (CSP) provides the scientific community at large with access … of disciplines. Three calls fall under the umbrella of our CSP: The Large Scale call is for expansive projects that … the completion of a project, the JGI makes the assemblies, gene annotations, and analyses available to the community at …