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… of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … that example, was it the case where that colleague saw a potential mechanism for why there would be this … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… And at the time, it was really exciting when people would sequence [DNA]. The genome was– well, that hadn’t really … It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … not been previously evaluated. So we started to see this potential of looking for compounds based on these gene …

… oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that … usually serve as dimers, and then they will bind to certain sequences of DNA. And when they bind to those certain … this really, really interesting. Is there an opportunity potentially for them to come work in the lab and actually do …

… Our research focuses on the assembly of metagenomic sequence data into microbial genomes, which is of … ecology and metabolism by elucidating the functional potential of hard-to-culture microorganisms. This process enables our users to explore the genetic makeup of microbial communities, shedding light on …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … wise maybe, what genome mining is, then, is looking at DNA sequence and trying to find the things that you want to …

… the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … other compounds that are produced, and we don’t know what potentially other targets, if there are actually other … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …

… Science One of the most vital pieces of equipment for fly fishing is a boxful of lures. Designed with feathers or … of microbial enzymes, which could have a plethora of potential applications to industrial processes. Summary JGI …

… technology to help access complicated natural product gene clusters, and we’re all really excited about that, and … and enabling technology, but interesting biology and a potential application of translation in medicine. So it’s a … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … products work, right? Think about how many things that are potential drug molecules that have micromolar activities. … to some people more about down the road. Email Nigel! He’ll sequence whatever you want!  [LAUGHTER]  NIGEL MOUNCEY: We …

… capabilities and products . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA … and 200 polar/500 nonpolar metabolomics samples, and should generally conform to the guidelines for our  CSP Large Scale … are strongly encouraged to contact the JGI to determine general feasibility prior to submitting a BER proposal that …

… Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … the program enables the design and synthesis of complex genetic pathways and biosystems. It The program fosters … Program aims to generate large datasets to explore sequence-function relationships, advancing the discovery of …

… association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh Alison sequenced all of these, she tried this, if you have this … could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: …