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… 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science … 2018, Molecular Cell 2019) and massive reconstruction of genomes from uncultivated microbes (Nature 2019). Other projects in … Nayfach S, et al. (2021) CheckV assesses the quality and completeness of metagenome-assembled viral genomes. Nature …

… lot going on, so I took a little break, but I’m hoping that from here I can get back to a regular schedule. I’m going to … and the stabilized isotope probing work that we’re doing, single cell work we’re doing. And using these together along … that’s your turf.  NIGEL MOUNCEY: Yeah, great.  DAN: And completely free, right?  NIGEL MOUNCEY: It is completely …

… over our interview with Dr Elizabeth (or Betsy) Parkinson from Purdue University. She’s in the Department of Chemistry … with known receptors, but we also have ones that are completely their own cluster. And so we're hypothesizing … in is actually seeing whether we could go into the genomes and predict what the natural product might actually …

… prefers to be known among friends in natural products. He’s from Langebio in Irapuato, Mexico, and an incredibly bright … If we are only interested in that final product, which is completely potent and specific to the target we’re thinking … it is more related to what JGI does, which is sequence genomes. And we just published last year in the Nature …

… real legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill … know, I’m here to find a job. I would like to do something completely new. And that is to begin to study the organic … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … yes, sure, right. And yeah, so we worked on the Salinospora genomes. That was a really fun project. We had Brad on and … why we had the idea that the microviridins also could be completely different compounds. But that got at the idea …

… we get to present our conversation with Marnix Medema , from Wageningen University in the Netherlands. Marnix is still pretty young, but he’s been dead center and a lot of … and a tool for predicting natural product structures from genomes. And I was writing grants furiously to try to get …

… and bioproducts. By sequencing and analyzing the genomes of these organisms, the program investigates the … culture collections to produce hundreds of diverse algal genomes, which will be made accessible through the PhycoCosm … for microbial eukaryotes, build fungal and algal pangenomes, and integrate multi-omics tools to enhance …

… in the project by watching Amanda Hurley’s presentation from the 2019 JGI Genomics of Energy & Environment Meeting.] … the secondary metabolism side of things was looking at genomes and seeing where the really hard things to sequence … something like soil, which I’m working on now, this is a complete black box, we’re talking many, many orders of …

… the University of Hawaii and moved there in the early ’60s from Berkeley to work on this new budding field of marine … Sequencing Program, and they worked with us to sequence two genomes. Those were of Salinospora tropica and arenicola . … or they can store that chemical – or they can store the cells, as well. And so we’re hoping initially to be able to …

… Laboratory. Being a User Facility means that scientists from all over the world bring us big problems related to … they figured out that they could culture the plant cells and produce enough that way in really large like 7500 … is sort of the old, older fashioned term for it. And it’s still around. But if you Google “natural products”, you’re …

… Proposals accepted before FY22 are transitioning away from producing use-restricted data. JGI proposals typically … based on scientific need. Proposals are considered complete when all agreed-upon projects are complete. This … to the 2-year use-restriction policy as described here. No single project has data under both use-restriction and …