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I-Min (Amy) Chen
… her Ph.D. in Computer Science. Her research has been focused on semantic and object-oriented data modeling, and … the Object-Protocol Model (OPM) data management tools for scientific applications developed at Berkeley Lab. Dr. Chen … S et al. IMG/VR v4: an expanded database of uncultured virus genomes within a framework of extensive functional, …
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How Maize Makes An Antibiotic Cocktail
… a family of compounds that protects it against infections — using surprisingly few enzymes. The Science Maize ( Zea mays … scientists have identified at least 15 zealexins, they suspect there are even more to find. Zealexins are produced … a dozen enzymes. But researchers have now revealed that just a handful of enzymes are needed to transform zealexins …
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A New Actinobacterial Chapter in the Genomic Encyclopedia of Bacteria and Archaea
… analysis leads to identification of biosynthetic gene clusters for novel secondary metabolites for multiple … information as well as of important descriptive metadata about each strain. “This has been a very fruitful … and computational analysis that enable systems-based scientific approaches to these challenges.  DOE’s Office of …
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An Integrated Dataset to Understand Ecosystem Interaction
… and how healthy they are, a recent data set  outlined in  Scientific Data connects molecular features to large … time. By collecting data from 27 different poplar ( Populus trichocarpa ) trees, as well as the soil surrounding … wildlife habitats and water-quality regulation. Focusing on the rhizosphere and interactions between the trees, …
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Refining the Process of Identifying Algae Biotechnology Candidates
… ] The Science The recipe for growing algae as a source of sustainable biofuels seems fairly simple: place these algae … feedstocks that can thrive in saltwater mitigates concerns about diverting resources such as arable land and fresh … to various stresses, and its transcriptome to learn more about which genes expression patterns. The analysis led to …
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Learning to Look
Machine learning approach significantly expands inovirus diversity. To answer the question, “Where’s Waldo?” … (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility, developed an algorithm that a computer could … work also used resources of the  National Energy Research Scientific Computing Center , another DOE Office of Science …
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An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria
… is central to our ability to offer host-engineering for our users,” says JGI Director Nigel Mouncey. Using CRAGE, JGI has established a portfolio of microbial … practice ideas presented in a  Trends in Biotechnology  review piece by Yoshikuni and JGI colleagues Jing Ke and …
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From Competition to Cooperation
… walls, while brown rot cannot break down the lignin but use cellulose. Finally, there are soil saprotrophs, which … in moving toward functional genomics studies to learn more about the inner workings of plant-host and … Regional Development Fund and the Plant-Microbe Interfaces Scientific Focus Area in the Genomic Science Program, the …
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Getting to the Bottom of Fungal Functions Across Earth’s Forests
… carbon and cycle key nutrients like nitrogen and phosphorus.  This way, the fungi of forest soils hold keys to tree … give researchers a way to access much more information about fungi in these environments. “Now with these new tools … and computational analysis that enable systems-based scientific approaches to these challenges.  DOE’s Office of …
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Zhong Wang
Research in the Analysis R&D group focuses on developing new bioinformatics solutions to support … and external scientists, the Wang group has developed customized data analyses and software to enable “grand-scale” scientific projects. These solutions include large-scale …
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Single-cell enabled comparative genomics of a deep ocean SAR11 bathytype
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Dynamics and activity of an ammonia-oxidizing archaea bloom in South San Francisco Bay
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