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Large-scale comparative analysis leads to identification of biosynthetic gene clusters for novel secondary metabolites for multiple … have uncovered genomes for just a small fraction of Earth’s microbial diversity. Because most microbes cannot be …

A preview of how large-scale single cell genomics complements metagenomics studies. The Science Researchers … that species specific sets of single cells harbored mobile genetic elements that were missed within paired metagenome … of bioinformatics tools for  extracting snippets of microbial genomes directly from environmental sequence data, …

… a technique for  c hassis (or strain)-independent  r ecombinase- a ssisted  g enome  e ngineering ( CRAGE ). CRAGE … Mouncey. Using CRAGE, JGI has established a portfolio of microbial hosts that users can select to be engineered. … domesticate some 60 strains, inserting into them a genetic sequence that acts as a “landing pad.” Mouncey adds, …

CRAGE-CRISPR combo helps further demystify biosynthetic gene clusters.  The Science Microbial secondary metabolites, those molecules not …

Biology Knowledgebase (KBase), the National Microbiome Data Collaborative (NMDC), and Berkeley Lab Biosciences Area are … use of our data. We completed 39,870 projects in FY24 We generated 871 Terabases of sequence We synthesized 9.7 … processed 13,700 metabolomics samples With our users, 247 publications were published   … Our primary objective is to …

Analysis reveals cotton genome stability across global lineages . Come … authors of the  paper published April 20, 2020 in  Nature Genetics include Jane Grimwood and Jeremy Schmutz of JGI’s  … Science “The results described in this  Nature Genetics publication will facilitate deeper understanding of cotton …

Gene expression in eukaryotes was long held to be … – that is, a single gene makes messenger RNA, which encodes a single protein. Gene expression in eukaryotes was … the genes of one of our species of algae and kept seeing what looked like mistakes by the gene prediction algorithms. …