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Rex Malmstrom
… growth rates and carbon consumption of SAR11 bacteria, the most abundant bacterial group in the ocean. Later during his postdoctoral work at the Massachusetts Institute of … University of Delaware BA in Biology, Boston University ( magna cum laude ) …
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Fungal Friends or Foes in Plant Roots
… between plant roots and fungi that can help or harm plant host health. The Science Researchers compared the genomes of … the plant’s health and diversity, which can in turn boost yields for both food and for candidate bioenergy … . They looked for genes known to be involved in fungal-host interactions and identified 84 gene families that were …
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Plotting a Model for Virus-Host Warfare Deep Below Ground
… the viruses repeatedly attempted to infect and destroy the host archaea – and how the  microbes resist. The battle waged … lyse the microbial cells. This demonstration of the virus-host arms race in uncultivated yet abundant subsurface … are using Altiarchaea as a model system to study virus-host interactions. Approximately 150 archaeal viruses had …
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Simon Roux
… of new experimental approaches to link viruses to their host(s), collaboration with JGI users for analyzing viral … foundational knowledge of viral diversity and virus-host interactions in microbial systems. Through a 2021 DOE … explore the ecological and evolutionary drivers of virus-host dynamics in soil microbial communities. …
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The Expanding Universe of Methane Metabolisms in Archaea
… propose a scenario where methanogenesis is possibly the most ancient energetic metabolism in the Archaea, and was lost many times independently during archaeal evolution or …   One genome, two metabolic pathways “Up to this point, most phylogenomic trees have relied on only one korarchaeotal …
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A Revamped Amplification Method that Enables Nearly Complete Single-Cell Genomes
… useful for understanding the microbiome of the earth, but most species do not grow easily in the lab. To access the … a method called Multiple Displacement Amplification, and most genomes that were acquired through it were usually only … (PTA) yields a much higher completion, above 80% in most cases. The Impact PTA is a refined capability that is …
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DAP-seq Drives Robust Mapping of Gene Regulation
… dataset of improved quality; deep insights identify the most important binding sites by leveraging trends in … all at once. That let us profile more cells for the same cost, and it actually made the data cleaner.”   By … sites, researchers can hone in on and identify the most critical regulatory elements that contribute to plant …
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Enlarging Windows into Understanding Gene Functions
… innovative way to rapidly capture the binding location for most transcription factors in a species,” O’Malley said. … of a streamlined workflow that reduces the time and cost associated with this purification step, and Baumgart … dataset from months to days and halving the total reagent cost. While Biotin DAP-seq can be used by itself, it can also …
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JGI@25: Expanding Metagenomics to Capture Viral Diversity
… carbon cycles. “Whether or not you planned it, viruses are most likely in your system and in your data, and they’re … they often need unique conditions and a specific microbial host to replicate. Sequencing genetic material directly from … of this field, the JGI has leveraged metagenomics to boost understanding of environmental viruses. In 2016, Nikos …
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Charting Progress toward Professional Goals
… Genomic data scientist Deanna Beatty sat down with interns hosted at the JGI through three different internship programs … you wanted to share about it? Jehan Jacobs : I have a poster session actually, like just a couple days from now. So … challenge for me was my research results not being the most promising. Going into the project, like, I kind of knew …
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JGI-Enabled Research Demonstrates the Existence of New Methane-Makers
… a potent greenhouse gas, regulate Earth’s climate. Most methane is produced in environments without oxygen … . These ancient, single-celled organisms thrive in most  environments devoid of oxygen and until recently were … look if these genes are expressed, you have to be very agnostic and very careful,” Hatzenpichler explained. “Not only …
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Extracting the Secrets of Secondary Metabolites
… CRAGE, researchers are no longer limited to using model host microbes; theoretically, any microbe can serve as the … Lab) can then employ CRISPR in a variety of microbial hosts. Summary Photorhabdus luminescens proves fatal to … toxins into the insect’s bloodstream that quickly kill the host. Understanding exactly how P. luminescens and its …
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