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Boosting Small Molecule Production in Super “Soup”
… still work in cell-free environments? (Spoiler: Yes.) Think of cells as tiny factories: within their walls they have … , researchers led by Hal Alper at The University of Texas at Austin and Michael Jewett of Northwestern … Program at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User …
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Trent Northen
… Northen’s research is focused on using metabolomics to link genomes with environments to understand how webs of microbes cycle carbon and sustain biomes via the development and application of advanced mass spectrometry approaches and model … at the JGI. Click to learn more about the program's areas of focus, major initiatives and more.  …
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A Plant Root Atlas for Tracking Developmental Trajectories
… A collaborative team led by Geoffrey Schiebinger at the University of British Columbia, Philip Benfey at Duke University and … scientist at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science …
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Boosting Small Molecule Production in Super “Soup”
… Yeast strains engineered for the biochemical conversion of glucose to value-added products are limited in chemical … an alternative format for chemical synthesis in the absence of cell growth by isolating the soluble components of lysed … Program at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User …
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You Can Move, But You Can’t Hide
… to replicate themselves and spread from cell to cell. Two of the most common forms of MGEs are viruses and plasmids. … MGEs based upon their gene content and their genetic sequences. The software was created by researchers under the … Lead Nikos Kyrpides at the U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility at …
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Hiroshi Otani
… Since joining the DOE Joint Genome Institute in 2016, Dr. Otani has been studying … technologies and methodologies that facilitate discovery of new secondary metabolites. Prior to joining the JGI, he … BS, Engineering, Tokyo Institute of Technology Master's, Biotechnology, University of Tokyo …
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Fishing for Novel Cellulose Degraders
… genomic approach to bioprospecting. The Science One of the most vital pieces of equipment for fly fishing is a boxful of lures. Designed … by Tanja Woyke at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User … The work conducted by the U.S. Department of Energy Joint Genome Institute, a DOE Office of Science …
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What Happens Underground Influences Global Nutrient Cycles
… for User Science (FICUS) program, two Department of Energy (DOE) Office of Science national user facilities—the  … Molecular Sciences Laboratory (EMSL) and the  DOE Joint Genome Institute (JGI)—have selected 11 proposals for … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science …
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A Pinch of Salt Activates Silent Gene Clusters in Streptomyces
… chemical factories. They hold genetic blueprints for dozens of complex compounds, but stay largely dormant under … Researchers with the Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science user … The team also identified previously unknown promoter sequences within these gene clusters, offering new …
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Streamlining Regulon Identification in Bacteria
… with their target genes. The Science Regulons are a group of genes that can be turned on or off by the same regulatory … in Streptomyces coelicolor . The Impact As an integrative genome science user facility, connecting genes to functions … the 5’-ends by 5’-end sequencing, from which those promoter sequences recognized by a given sigma factor are inferred. …
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Gut Fungi: Unexpected Source of Novel Chemicals
… The Science Anaerobic fungi, which die in the presence of oxygen, dwell in herbivore guts and help them digest … called natural products . Yet, combing through the genomes of four anaerobic fungal species has revealed, for … finnis . In work reported in 2017, the fungal genomes were sequenced by the U.S. Department of Energy (DOE) Joint …
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Matthew Kellom
… places that are considered to be inhospitable to humans are of particular interest. Matt also supports various CSP and FICUS user projects for the Metagenome Program. …
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