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A restricted spectrum of NRAS mutations causes Noonan syndrome
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The protist Aurantiochytrium has universal subtelomeric rDNAs and is a host for mirusviruses
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JGI Early Career Researchers Featured in mSystems Special Issue
… In a special issue of mSystems , out May 14, 2019, JGI … who offer perspectives on what the next five years of innovation could look like. In one article, Micro-Scale … cell sorting (FACS) to sort cells into several small pools before sequencing to recover rare microbes. The …
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Pinning Down a Piece of Photosynthesis
… By studying the structure and function of a cyanobacterial protein, researchers have new insights into how these ocean photosynthesizers cycle carbon … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility located at …
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Tracking the Origins of Methane-Producing Microbes
… Mini-Metagenomics Approach Helps Identify Novel Archaeal Methane Metabolism. Methane-producing archaea are estimated to produce 500 million tons of … to these samples by sorting the microbes into small pools of cells that were then sequenced separately. … The U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility …
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How Maize Makes An Antibiotic Cocktail
… Maize produces a family of compounds that protects it against infections — using surprisingly few enzymes. The Science … plants in addition to maize, including the bioenergy crop switchgrass. The team confirmed just how important zealexins … sesquiterpenoids, National Science Foundation Plant-Biotic Interactions Program (grant no. 1758976 to E.S. and P.Z.) …
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Here, There and Everywhere: Large and Giant Viruses Abound Globally
… diversity of large and giant viruses. While the microbes in a single drop of water could outnumber a small city’s population, the number of viruses in the same … eukaryotes, and they range in particle and genome size from small, to large and even giant. The genomes of giant viruses …
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Learning to Look
… Machine learning approach significantly expands inovirus … called inoviruses, which are filamentous viruses with small, single-stranded DNA genomes and a unique chronic … turn affecting the microbe’s own eukaryote host. As their small genomes can be easily manipulated through genetic …
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Training the Next Generation of Talent
… New Graduate Internship Program Builds Bridges Between DOE JGI, UC Merced … RNA-Seq assembly. RNA-Seq is a technique for profiling the small fraction of a genome that contains transcribed … “This is the first iteration of this program and we started small with just two people,” Visel says. “They were directly …
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A Pinch of Salt Activates Silent Gene Clusters in Streptomyces
… This single environmental trigger highlights efficiency for users requiring multiple omics methods to examine microbial chemical … dozens of growth conditions and found that adding a small amount of common salt to the Streptomyces coelicolor … This work conducted by the U.S. Department of Energy Joint Genome Institute (https://ror.org/04xm1d337), a DOE …
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An Integrated Dataset to Understand Ecosystem Interaction
… yields a comprehensive tree and soil dataset for understanding the dynamic relationship between poplar trees and their … work and how healthy they are, a recent data set  outlined in  Scientific Data connects molecular features to … Metabolomics allowed them to then examine the chemicals and small molecules produced by the trees and associated …
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Fishing for Novel Cellulose Degraders
… A “bait and hook” single-cell genomic approach to bioprospecting. The Science One of the most vital pieces of equipment … cell sorting to sort cells into several small pools, followed by whole genome amplification and … The work conducted by the U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, …
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