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User Executive Committee Charter
… users and their science including technical capabilities offered, proposal review procedures, and the annual user … recommendations to the JGI regarding technical capabilities offered, including areas where more or less capacity is … annual JGI User Meeting, as well as input on other aspects of the meeting such as duration, location, and cost; …
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How to Target a Microbial Needle within a Community Haystack
… A workflow for capturing the genetic make-up of specific uncultivated microbes from complex environmental … and then efficiently retrieve and characterize their genomes. The Impact Despite great strides in generating … for members of the microbial world through bulk community sequencing (metagenomics) and single-cell genomics, the vast …
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DAP-seq Drives Robust Mapping of Gene Regulation
… Multi-species assays yield an unprecedented view of plant evolution and adaptation.    Understanding how … to technical limitations and the sheer complexity of plant genomes. Now, with improvements to DNA Affinity Purification Sequencing (DAP-seq), these barriers are falling. As  …
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Obtaining genomes from uncultivated environmental microorganisms using FACS–based single-cell genomics
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A Natural Mechanism Can Turbocharge Viral Evolution
… Understanding how a fundamental mechanism of evolution allows microbes to adapt to changing … ago, a team discovered a group of viruses that had in their genomes a surprising tool: a “diversity generating … and viral genomes, as well as genomes sampled all at once from the same environment, called metagenomes. Why? Simon …
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JGI@25: Tracking & Subduing the Plague of California’s Oak Woodlands
… In honor of the JGI's 25th anniversary in 2022, we have revisited a … challenges.   Scanning the California oak woodlands from the air, large swaths of the bleached, skeletal remains … was released to the public in a highly-cited 2006 publication in the journal Science . This provided a …
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Cell by cell: population genetics in the wild
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Interdisciplinary delegation from the University of Duisburg-Essen explores collaborative opportunities with Lawrence Berkeley National Laboratory
… A two-day kick-off meeting held at Lawrence Berkeley National Laboratory … the visit of an esteemed interdisciplinary delegation from the University of Duisburg-Essen (UDE), Germany with … SITES Research Center (ACSI), the Centre for Water and Environmental Research (ZWU) of the University of …
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JGI@25: Using Team Science to Build Communities Around Data
… In honor of the JGI's 25th anniversary in 2022, we have revisited a … “We currently have 19 genomes sequenced, 15 that are in sequencing or assembly right now, and eight more that we are … genomes that are both large and complex. The first publication of a genome generated by the OGG initiative — …
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Innovative Technology Improves Our Understanding of Bacterial Cell Signaling
… di-GMP (Guanine Monophosphate) is found in nearly all types of bacteria and interacts with cell signaling networks that … Additionally, all plants, many bacterial cultures, and environmental samples auto-fluoresce, making fluorescent … changes in cyclic di-GMP via live cell imaging. Summary From digestive tracts to plant surfaces and soil, bacteria …
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Gene Expression: From On-Off Switch to Dial
… to expression, scientists can now opt for various shades of grey. The ability to fine-tune the level of gene … the production of betaxanthins. They used combinations of single guide RNA, or a single RNA piece that recognizes a … area in the DNA, to determine which targets might benefit from an intermediate level of expression. Similar to the …
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Nandita Nath
… in developing new methods to improve genome recovery from single cells and to build sequencing libraries from minimal DNA input without …
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