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… want to go back and listen to the first two parts ( part 1 is here and part 2 is here ) so you understand what’s … the number was. But I want to say it was like less than 10. Since, you know, a recent decade.  DAN: I’m sure that’s … to check her stat and she was absolutely correct. Since 2010 there have been eight new antibiotics added to the …

… pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … Brad: Yeah, at that time, that was new, right? Like, my god 10% of the genome makes small molecules that have, you know, … of changed over the years. And I think maybe over the last 10 years, I’ve really become a fan of having postdocs, and …

And I set that up. And we finally got that to work 10 years later. But in the meantime there, we had people … a teaspoon of soil from outside, you maybe have to do a 10,000-fold dilution to plate that out. The deeper you go in the cave, the less dilution. You can be down to 1 on 100 in a deep portion of a cave. So it just– it really, …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … lactone signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings DA Jr. … 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

… who was working on these things in the very early 1900s.  DAN: And so he has drawn what he called … molecules and their discoveries over a stretch from 1940 to 2000. As you can see, from the 1940s, into the 50s into the 60s, there was a huge growth – …